期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/ijms23168879
关键词
COVID-19; cytokines; multiplex; chemokines; growth factors
资金
- Ministry of Science and Higher Education of the Russian Federation [075-15-2022-301]
This study investigated the levels of cytokines in patients with moderate and severe COVID-19 and found elevated levels of pro-inflammatory factors, chemokines, anti-inflammatory factors, and growth factors. Patients with severe disease had higher levels of FGF-2/FGF-basic, IL-1 beta, and IL-7 compared to healthy donors. Pneumonia lung injury was positively correlated with levels of EGF, IP-10, and MCP-3, and negatively correlated with IL-12 p40. Pro-inflammatory factors were negatively correlated with the frequency of circulating Th17-like cells and follicular Th cells.
Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was to describe cytokine storm signatures in patients with acute COVID-19 and to investigate their influence on severity of the infection. Plasma levels of 47 cytokines were investigated in 73 patients with moderate and severe COVID-19 (41 and 32, respectively) and 11 healthy donors (HD). The most elevated levels comparing patients and the HD were observed for seven pro-inflammatory cytokines (IL-6, IL-8, IL-15, IL-18, IL-27, IFN gamma, TNF alpha), three chemokines (GRO alpha, IP-10, MIG), two anti-inflammatory cytokines (IL-1RA, IL-10), and two growth factors (G-CSF, M-CSF). The patients with severe disease had significantly higher levels of FGF-2/FGF-basic, IL-1 beta, and IL-7 compared to the HD. The two groups of patients differed from each other only based on the levels of EGF, eotaxin, and IL-12 p40. Pneumonia lung injury, characterized by computer tomography, positively correlated with levels of EGF, IP-10, MCP-3 levels and negatively with IL-12 p40. Pro-inflammatory factors including IL-6, TNF alpha, and IP-10 negatively correlated with the frequency of the circulating T-helper17-like cells (Th17-like) and follicular Th cells that are crucial to develop SARS-CoV-2-specific plasma cells and memory B cells. Obtained data on the cytokine levels illustrate their influence on progression and severity of COVID-19.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据