4.7 Article

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Inhibitors of PARP: Number crunching and structure gazing

Johannes Rudolph et al.

Summary: Selective inhibitors of PARP1 and PARP2 are used for treating cancer patients with DNA repair deficiencies. Talazoparib shows higher potency compared to other inhibitors due to its extensive interactions with conserved residues in the active site. The recently characterized protein HPF1 may play a role in designing the next generation PARP1/2 inhibitors.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Review Biochemistry & Molecular Biology

PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols

Natalya V. Maluchenko et al.

Summary: PARP-1 plays crucial roles in cell cycle regulation, DNA repair, transcription, and replication, with its hyperactivity promoting chronic pathological processes and moderate activation supporting tumor cell survival. Therefore, PARP inhibitors are considered promising agents for the treatment of tumors and metabolic diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Mechanisms of Nucleosome Reorganization by PARP1

Natalya V. Maluchenko et al.

Summary: The mechanisms of PARP1-nucleosome interaction are still unknown, with potential for PARP1-induced nucleosome reorganization to form an alternative state likely involved in gene regulation and DNA repair.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context

M. M. Kutuzov et al.

Summary: The study revealed that the presence of PARP1 leads to the suppression of BER enzymes' activities, while PARP2 predominantly influences the last stage of BER. PARylation attenuates the inhibitory effect of PARP1, but results in Pol beta inhibition and significant stimulation of LigIII alpha by PARP2 in a NAD(+)-dependent manner.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling

Lotte van Beek et al.

Summary: PARP 1-3 are multi-domain enzymes known for catalyzing covalent modification of proteins, DNA, and themselves, with important functions in DNA damage response and nucleosome remodelling. Activation of PARP occurs through DNA binding, and modulation of their activity with PARP inhibitors has shown success in cancer therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

PARP-1 Regulates Estrogen-Dependent Gene Expression in Estrogen Receptor α-Positive Breast Cancer Cells

Shrikanth S. Gadad et al.

Summary: PARP-1 plays a crucial role in regulating estrogen-dependent gene expression in ER+ breast cancer cells, impacting cell proliferation. High expression of PARP1 is associated with poor prognosis, suggesting PARP inhibitors as a potential therapeutic approach for ER+ breast cancer.

MOLECULAR CANCER RESEARCH (2021)

Review Biochemistry & Molecular Biology

Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity

Travis Eisemann et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Article Biochemical Research Methods

Time-resolved analysis of transcription through chromatin

Han-Wen Chang et al.

METHODS (2019)

Article Multidisciplinary Sciences

Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins

Han-Wen Chang et al.

SCIENCE ADVANCES (2018)

Article Biochemistry & Molecular Biology

Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci

Ziying Liu et al.

MOLECULAR CELL (2017)

Article Genetics & Heredity

Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy

Daniel Sultanov et al.

AIMS GENETICS (2017)

Article Biochemistry & Molecular Biology

Global Transcriptome Analysis Reveals That Poly(ADP-Ribose)Polymerase 1 Regulates Gene Expression through EZH2

Kayla A. Martin et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

PARPs and ADP-Ribosylation: 50 Years ... and Counting

W. Lee Kraus

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

Sebastian Eustermann et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Structural analysis of nucleosomal barrier to transcription

Daria A. Gaykalova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation

Narasimharao Nalabothula et al.

PLOS ONE (2015)

Review Pharmacology & Pharmacy

Trapping Poly(ADP-Ribose) Polymerase

Yuqiao Shen et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Article Oncology

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

Junko Murai et al.

MOLECULAR CANCER THERAPEUTICS (2014)

Article Biochemistry & Molecular Biology

Analysis of the mechanism of nucleosome survival during transcription

Han-Wen Chang et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Multidisciplinary Sciences

Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone

Uma M. Muthurajan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biochemistry & Molecular Biology

Poly-ADP-ribose polymerase: Machinery for nuclear processes

Colin Thomas et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Article Biochemistry & Molecular Biology

Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

Stephanie Jungmichel et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Histone chaperone FACT action during transcription through chromatin by RNA polymerase II

Fu-Kai Hsieh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Oncology

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

Junko Murai et al.

CANCER RESEARCH (2012)

Article Biochemistry & Molecular Biology

Alternative Modes of Binding of Poly(ADP-ribose) Polymerase 1 to Free DNA and Nucleosomes

Nicholas J. Clark et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Histone ADP-Ribosylation Facilitates Gene Transcription by Directly Remodeling Nucleosomes

Ricardo Martinez-Zamudio et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Activator-Induced Spread of Poly(ADP-Ribose) Polymerase Promotes Nucleosome Loss at Hsp70

Steven J. Petesch et al.

MOLECULAR CELL (2012)

Article Multidisciplinary Sciences

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

Marie-France Langelier et al.

SCIENCE (2012)

Review Genetics & Heredity

Overcoming the nucleosome barrier during transcript elongation

Steven J. Petesch et al.

TRENDS IN GENETICS (2012)

Review Cell Biology

The roles of PARP1 in gene control and cell differentiation

Yingbiao Ji et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2010)

Article Biochemistry & Molecular Biology

PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway

Raga Krishnakumar et al.

MOLECULAR CELL (2010)

Article Multidisciplinary Sciences

RNA polymerase complexes cooperate to relieve the nucleosomal barrier and evict histones

Olga I. Kulaeva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Mechanism of histone survival during transcription by RNA polymerase II

Olga Kulaeva et al.

TRANSCRIPTION-AUSTIN (2010)

Article Biochemistry & Molecular Biology

Mechanism of chromatin remodeling and recovery during passage of RNA polymerase II

Olga I. Kulaeva et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Medicine, General & Internal

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers.

Peter C. Fong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Biochemistry & Molecular Biology

Rapid, transcription-independent loss of nucleosomes over a large chromatin domain at Hsp70 loci

Steven J. Petesch et al.

Article Biochemistry & Molecular Biology

CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery

Tiziana Guastafierro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Histone N-terminal Tails Interfere with Nucleosome Traversal by RNA Polymerase II

Andrea Ujvari et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes

Raga Krishnakumar et al.

SCIENCE (2008)

Review Biotechnology & Applied Microbiology

Transcription through chromatin by RNA polymerase II: Histone displacement and exchange

Olga I. Kulaeva et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2007)

Article Biochemistry & Molecular Biology

Nucleosomes can form a polar barrier to transcript elongation by RNA polymerase II

Vladimir A. Bondarenko et al.

MOLECULAR CELL (2006)

Article Biochemistry & Molecular Biology

Nature of the nucleosomal barrier to RNA polymerase II

ML Kireeva et al.

MOLECULAR CELL (2005)

Article Biochemistry & Molecular Biology

Nucleosome remodeling induced by RNA polymerase II: Loss of the H2A/H2B dimer during transcription

ML Kireeva et al.

MOLECULAR CELL (2002)