Therapeutic Benefits of Selenium in Hematological Malignancies

Supplementing chemotherapy and radiotherapy with selenium has been shown to have benefits against various cancers. This approach has also been shown to alleviate the side effects associated with standard cancer therapies and improve the quality of life in patients. In addition, selenium levels in patients have been correlated with various cancers and have served as a diagnostic marker to track the efficiency of treatments or to determine whether these selenium levels cause or are a result of the disease. This concise review presents a survey of the selenium-based literature, with a focus on hematological malignancies, to demonstrate the significant impact of selenium in different cancers. The anti-cancer mechanisms and signaling pathways regulated by selenium, which impart its efficacious properties, are discussed. An outlook into the relationship between selenium and cancer is highlighted to guide future cancer therapy development.

Automated summary

Supplementing chemotherapy and radiotherapy with selenium has shown beneficial effects against various cancers and can alleviate side effects while improving patients' quality of life. Selenium levels have been correlated with different cancers and can serve as diagnostic markers for tracking treatment efficiency and determining the relationship between selenium levels and the disease. This review provides an overview of the significant impact of selenium in different cancers, discussing its anti-cancer mechanisms and signaling pathways.