期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms23158473
关键词
chronic inflammatory diseases; inflammatory bowel disease; IgG glycosylation; response; personalized medicine; autoimmune diseases
资金
- European Union [733100]
- DFG
Immunosuppressants and biologicals impact the glycosylation of serum immunoglobulin G (IgG) in patients with chronic inflammatory diseases (CID). The study reveals a decrease in IgG glycosylation in CID patients, while an increase in glycosylation is observed in patients undergoing therapy and in remission.
Immunosuppressants and biologicals are widely used therapeutics for various chronic inflammatory diseases (CID). To gain more detailed insight into their downstream effects, we examined their impact on serum immunoglobulin G (IgG) glycosylation. We analyzed IgG subclass-specific fragment crystallizable (Fc) N-glycosylation in patients suffering from various CID using the LC-MS approach. Firstly, we compared IgG Fc N-glycosylation between 128 CID patients and 204 healthy controls. Our results replicated previously observed CID-related decrease in IgG Fc galactosylation (adjusted p-value range 1.70 x 10(-2)-5.95 x 10(-22)) and sialylation (adjusted p-value range 1.85 x 10(-2)-1.71 x 10(-18)). Secondly, to assess changes in IgG Fc N-glycosylation associated with therapy and remission status, we compared 139 CID patients receiving either azathioprine, infliximab, or vedolizumab therapy. We observed an increase in IgG Fc galactosylation (adjusted p-value range 1.98 x 10(-2)-1.30 x 10(-15)) and sialylation (adjusted p-value range 3.28 x 10(-6)-4.34 x 10(-18)) during the treatment. Furthermore, patients who reached remission displayed increased Fc galactosylation levels (p-value range 2.25 x 10(-2)-5.44 x 10(-3)) in comparison to patients with active disease. In conclusion, the alterations in IgG Fc glycosylation and the fact these changes are even more pronounced in patients who achieved remission, suggest modulation of IgG inflammatory potential associated with CID therapy.
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