期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms23147708
关键词
polypyridyl ruthenium (II) complexes; endothelial cells; angiogenesis; cell adhesion properties; cytotoxicity; migration; cell elasticity; focal adhesions; pseudovessel formation
资金
- National Science Center in Poland [2016/21/B/NZ7/01081, POWR.03.02.00-00-013/16]
- Labex SynOrg [ANR-11-LABX-0029]
- Labex IRON [ANR-11-LABX0018-01]
- FEDER TECHSAB
- University of Orleans
- Centre-Val de Loire Region
Polypyridyl Ru complexes can alter cell adhesion properties and inhibit endothelial cell migration and pseudovessel formation, thereby inhibiting angiogenesis.
The use of polypyridyl Ru complexes to inhibit metastasis is a novel approach, and recent studies have shown promising results. We have reported recently that Ru (II) complexes gathering two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and the one being 2,2 '-bipyridine (bpy) or its derivative with a 4-[3-(2-nitro-1H-imidazol-1-yl)propyl (bpy-NitroIm) or 5-(4-{4 '-methyl-[2,2 '-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (bpy-SC) moieties can alter the metastatic cascade, among others, by modulating cell adhesion properties. In this work, we show further studies of this group of complexes by evaluating their effect on HMEC-1 endothelial cells. While all the tested complexes significantly inhibited the endothelial cell migration, Ru-bpy additionally interrupted the pseudovessels formation. Functional changes in endothelial cells might arise from the impact of the studied compounds on cell elasticity and expression of proteins (vinculin and paxillin) involved in focal adhesions. Furthermore, molecular studies showed that complexes modulate the expression of cell adhesion molecules, which has been suggested to be one of the factors that mediate the activation of angiogenesis. Based on the performed studies, we can conclude that the investigated polypyridyl Ru (II) complexes can deregulate the functionality of endothelial cells which may lead to the inhibition of angiogenesis.
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