期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms23147965
关键词
GAD67; GAD65; VGAT; GABA; GABA-receptors; GABAergic transmission; glutamatergic transmission; neural development
资金
- National Health & Medical Research Council Australia [NHMRC 1188169, NHMRC 1065884]
- Motor Neuron Disease Research Australia (MNDRA) [GIV 1842]
- Fight MND translational grant
- University of Queensland PhD scholarships program
- MNDRA [1805]
The normal development and function of the central nervous system depend on a balance between excitatory and inhibitory neurotransmission. Down-regulated inhibitory signaling is associated with various neurological disorders. GABA is the primary inhibitory neurotransmitter in the mammalian forebrain and its down-regulated signaling is linked with multiple neurological diseases.
Normal development and function of the central nervous system involves a balance between excitatory and inhibitory neurotransmission. Activity of both excitatory and inhibitory neurons is modulated by inhibitory signalling of the GABAergic and glycinergic systems. Mechanisms that regulate formation, maturation, refinement, and maintenance of inhibitory synapses are established in early life. Deviations from ideal excitatory and inhibitory balance, such as down-regulated inhibition, are linked with many neurological diseases, including epilepsy, schizophrenia, anxiety, and autism spectrum disorders. In the mammalian forebrain, GABA is the primary inhibitory neurotransmitter, binding to GABA receptors, opening chloride channels and hyperpolarizing the cell. We review the involvement of down-regulated inhibitory signalling in neurological disorders, possible mechanisms for disease progression, and targets for therapeutic intervention. We conclude that transgenic models of disrupted inhibitory signalling-in GAD67(+/-) and VGAT(-/-) mice-are useful for investigating the effects of down-regulated inhibitory signalling in a range of neurological diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据