期刊
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
卷 27, 期 9, 页码 1459-1466出版社
SPRINGER JAPAN KK
DOI: 10.1007/s10147-022-02195-9
关键词
Complication; Diagnostic rate; Gelatin sponge; Genomic medicine; Liver biopsy
类别
This study evaluated the safety and feasibility of a liver tumor biopsy technique using a coaxial introducer needle and embolization with gelatin sponge particles. The results showed that this technique can safely and effectively collect specimens with a sufficient volume for modern cancer treatments.
Background With the evolution of personalized medicine in the field of oncology, which includes optimal treatment selection using next-generation sequencing-based companion diagnostic systems and tumor-agnostic treatments according to common biomarkers, a liver tumor biopsy technique that can obtain a sufficient specimen volume must be established. The current study aimed to evaluate the safety and availability of a liver tumor biopsy technique with multiple puncture sites made using a coaxial introducer needle and embolization with gelatin sponge particles. Methods Patients with primary or metastatic liver cancer who underwent liver tumor biopsies with puncture tract embolization using gelatin sponge (Spongel (R)) from October 2019 to September 2020 were included in the study. The complication and diagnostic rates were evaluated, and whether the specimen volume was sufficient for Foundation (R) CDx was investigated. Results In total, 96 patients were enrolled in this analysis. The median total number of puncture times per patient was 3 (range 1-8). The pathological diagnostic rate was 79.2%. Using the FoundationOne (R) CDx, specimens with a sufficient volume required for genomic medicine were collected in 84.9% of patients. The incidence rate of bleeding was 4.2% (n = 4), and only one patient presented with major bleeding requiring transfusion. Conclusions Liver biopsy with puncture tract embolization using a gelatin sponge may be safe and effective for collecting specimens with a volume sufficient for modern cancer treatments.
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