期刊
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
卷 54, 期 10, 页码 570-576出版社
WILEY
DOI: 10.1002/kin.21596
关键词
free-radical scavenging reaction; singlet-oxygen quenching reaction; solvent effect; vitamin E; water addition to ethanol
资金
- JSPS KAKENHI [JP18K05518]
The effects of solvent on the antioxidant reactions of vitamin E were investigated using stopped-flow and laser spectroscopies. The results showed that the rate constant of the aryloxyl-radical scavenging reaction by vitamin E increased with the addition of water, while the rate constant of the singlet-oxygen quenching reaction reached a maximum at around 10% water concentration and then decreased. The findings suggest that the antioxidant activities of vitamin E depend on its position in biomembranes.
Solvent effects on the activities of aryloxyl-radical (aroxyl-radical) scavenging and singlet-oxygen (O-1(2)) quenching reactions by vitamin E (alpha-tocopherol) were studied with stopped-flow and laser spectroscopies together with density functional calculations. Partial electron transfer from alpha-tocopherol plays an important role in an early step of each of these antioxidant reactions. To shed light on the solvent effects, we used ethanol as the reference solvent and added water to it. The rate constant of the aryloxyl-radical scavenging reaction by alpha-tocopherol increased monotonously by adding water to the ethanol solution, because the oxidation potential of alpha-tocopherol decreases as water is added. Although the rate constant of the O-1(2) quenching reaction similarly increased with increasing water concentration from 0% to 10% v/v, it reached a maximum at about 10% v/v and decreased in the range 10%-20% v/v. The suppression of the O-1(2) quenching in the 10%-20% v/v range could be attributed to complexes forming between O-1(2) and the water molecules. On the basis of the present results, we inferred how the antioxidant activities of alpha-tocopherol depend on its position in biomembranes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据