期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 213, 期 -, 页码 845-857出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.05.199
关键词
Chitosan-zinc complex; Chelation process; Wound healing; Antibacterial activity
资金
- European Union's Horizon 2020 research and innovation program [739566]
- SAS-MOST [JRP 2018/02]
- [APVV-190010]
We successfully prepared and characterized chitosan-Zn complex (ChiZn) films. The ChiZn showed controlled release of zinc, no toxicity towards cells, improved wound closure, and antibacterial activity. These findings suggest that ChiZn could be an effective wound healing agent.
We report the successful preparation and characterization of chitosan-Zn complex (ChiZn) in the form of films, intended to enhance the biological performance of chitosan by the presence of Zn as antibacterial agent and biologically active ion. The influence of Zn chelation on morphology and structure of chitosan was assessed by scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy and infrared spectroscopy. The biodegradability study of ChiZn showed a sustained release of Zn up to 2 mg/mL. No toxic response was observed toward stromal cell line ST-2 in indirect contact with the ChiZn films. The dissolution product of ChiZn showed improved wound closure (88% closure) compared to the positive control group (70% closure). Moreover, ChiZn exhibited antibacterial activity against S. aureus together with a slight increase (similar to 30%) in the secretion of VEGF and moderate decrease in nitric oxide evolution. Our findings indicate that ChiZn could be used as a safe and effective wound healing agent.
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