期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 213, 期 -, 页码 427-434出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.05.183
关键词
Silver nanoparticles; Electrospun alginate membranes; Antimicrobial properties
Polysaccharide-based composites embedding silver nanoparticles show promising antimicrobial properties due to the combination of effective biocidal properties of the silver nanoparticles and the biocompatibility and environmental safety of the naturally occurring polymeric component. The silver nanoparticles stabilized with alginate chains were successfully synthesized in situ and electrospun into nanocomposite membranes for potential antimicrobial applications.
Polysaccharide-based composites embedding silver nanoparticles (AgNPs) represent a promising alternative to common antimicrobial materials because of the effective, broad-spectrum biocidal properties of AgNPs combined with the biocompatibility and environmental safety of the naturally occurring polymeric component. In this work, AgNPs stabilized with alginate chains (Alg@AgNPs) were successfully synthesized in situ within the polysaccharide solution through a wet chemical approach carried out at different concentrations of the silver salt precursor. Once obtained, the aqueous suspensions were electrospun to prepare non-woven membranes, showing a homogeneous nanostructured texture (with fiber diameter between 100 and 150 nm), which was found to be influenced by the size (between 20 and 35 nm) of the embedded metal nanoparticles.The biocidal potential of the nanocomposite mats was preliminarily tested against Gram-negative E. coli. The results showed that the antimicrobial response of the investigated samples occurred within a day of incubation and can be observed for AgNPs content in the polysaccharide fibers far below the nanomolar regime.
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