期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 212, 期 -, 页码 314-323出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.05.138
关键词
Microcomposites; Halloysite nanotubes; Hemostasis; Chitosan; Lower gastrointestinal bleeding; Typhoid associated intestinal bleeding
资金
- Faculty of Pharmacy Bahauddin Zakariya University, Multan, Pakistan
- Higher Education Commission (HEC)
This study aimed to reduce the clotting time of lower gastro intestinal bleeding (LGIB) by using halloysite nanotubes (HNTs) and chitosan (CHT) microcomposites (MCs). The results showed that CHT/HNTs MCs had good procoagulant and hemostatic effects, and could be used for controlling bleeding disorders and providing antibacterial treatment.
Clotting time of lower gastro intestinal bleeding (LGIB) can be reduced by using simple, cost-effective, and naturally occurring halloysite nanotubes (HNTs). The present study aimed to decrease the clotting time by the application of chitosan (CHT) and its microcomposites (MCs) prepared by suspension emulsification technique with HNTs (CHT/HNTs MC). Physicochemical properties, X-Ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and percentage release of ciprofloxacin from CHT/HNTs MCs was evaluated. In-vitro procoagulant activity of CHT, HNTs and their complexes CHT/HNTs MCs was performed on rabbit blood which was confirmed by a rat tail amputation. Direct relation of HNTs was observed for the whole-blood clotting kinetics i.e., 2% HNTs showed a maximum 66.0% increase in the clotting ability as compared with pure CHT. Interestingly, rat-tail amputation studies showed comparative results of CHT, HNTs, and CHT/HNTs MCs. A total of 75% permeation of ciprofloxacin of CHT/HNTs MCs on rat intestinal membrane was observed within 3 h, confirming their SR behavior. Furthermore, improved hemostatic and clotting properties were CHT/HNTs MC1 > CHT/HNTs MC2 > CHT/HNTs MC3 > CHT > HNTs, respectively. Thus, it provided the control of bleeding disorders in LGIB with any antibacterial agents, particularly ciprofloxacin.
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