☆ 4.7 Article

BCG Vaccination: A potential tool against COVID-19 and COVID-19-like Black Swan incidents

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

Sequence similarity of HSP65 of Mycobacterium bovis BCG with SARS-CoV-2 spike and nuclear proteins: may it predict an antigen-dependent immune protection of BCG against COVID-19?

Paola Finotti

Summary: The BCG vaccine has protective effects against tuberculosis and potentially other diseases, including SARS-CoV-2, due to its non-specific enhancement of innate immunity. Sequence similarities between HSP65 of BCG and SARS-CoV-2 proteins suggest a potential cross-immune reaction.

CELL STRESS & CHAPERONES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Heterologous vaccination interventions to reduce pandemic morbidity and mortality: Modeling the US winter 2020 COVID-19 wave

Nathaniel Hupert et al.

Summary: COVID-19 remains a global health threat, and non-COVID-19 vaccines may have nonspecific effects that enhance population immunity and provide some protection against SARS-CoV-2 infection. Mathematical modeling suggests that heterologous vaccine interventions could reduce the spread and mortality of COVID-19, and these findings may be applicable to future viral pandemics.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Immunology

Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques

Andrew D. White et al.

Summary: The aerosol delivery of Bacille Calmette-Guerin (BCG) vaccine enhances innate immune mechanisms and non-conventional T-cell populations, providing cross-protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, aerosol BCG vaccination does not enhance initial virus clearance or reduce early disease pathology after high-dose SARS-CoV-2 challenge.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Large-Scale Structure-Based Screening of Potential T Cell Cross-Reactivities Involving Peptide-Targets From BCG Vaccine and SARS-CoV-2

Renata Fioravanti Tarabini et al.

Summary: The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus has resulted in over 4.5 million deaths worldwide. Despite the development of vaccines, the virus continues to spread globally due to resistance to vaccination and limited access to vaccines. Developing additional therapeutic strategies is crucial to combat SARS-CoV-2 and other coronaviruses.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Immunology

Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic

Ashok Aspatwar et al.

Summary: BCG vaccine plays a key role in reducing childhood mortality rates, protecting children against respiratory infections, lowering the risk of malaria, and providing immunity against respiratory infections in elderly people. Additionally, BCG also offers nonspecific innate immunity and has the potential to act as a protective agent against COVID-19.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

A Multi-Center, Randomised, Double-Blind, Placebo-Controlled Phase III Clinical Trial Evaluating the Impact of BCG Re-Vaccination on the Incidence and Severity of SARS-CoV-2 Infections among Symptomatic Healthcare Professionals during the COVID-19 Pandemic in Poland-First Results

Hanna Czajka et al.

Summary: A study in Poland found no significant correlation between BCG vaccination, tuberculin test results, scar numbers and the incidence of COVID-19. The only significant correlation observed was the type of medical profession.

VACCINES (2022)

添加到收藏夹

Article Microbiology

Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2

Oscar Rosas Mejia et al.

Summary: This study found that Mtb infection can enhance resistance to CoV2 infection, which is associated with the expansion of T and B cell subsets in the lungs.

PLOS PATHOGENS (2022)

添加到收藏夹

Article Immunology

Bacille Calmette-Guerin Vaccination in Infancy Does Not Protect Against Coronavirus Disease 2019 (COVID-19): Evidence From a Natural Experiment in Sweden

Clement de Chaisemartin et al.

Summary: A natural experiment in Sweden showed that discontinuation of newborn BCG vaccination led to decreased coverage rates and limited protective effects against COVID-19. Therefore, receiving the BCG vaccine at birth does not provide protection against COVID-19 among middle-aged individuals.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Are BCG-induced non-specific effects adequate to provide protection against COVID-19?

Vipin M. Vashishtha

Summary: The world is facing a pandemic of COVID-19 caused by SARS-CoV-2, with vaccination being the key prevention measure. BCG vaccine may play a positive role in reducing the incidence and mortality of COVID-19.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

添加到收藏夹

Article Virology

Convergence between global BCG vaccination and COVID-19 pandemic

Md. Zahurul Islam et al.

Summary: The novel coronavirus SARS-CoV-2 has caused a global crisis with COVID-19, while efforts to develop vaccines are ongoing and the potential protective effect of BCG vaccine in COVID-19 is being investigated. However, further research is needed to fully understand the implications of these interventions.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Intravescical instillation of Calmette-Guerin bacillus and COVID-19 risk

Ugo Fedeli et al.

Summary: There is currently no evidence to suggest that Bacillus Calmette-Guerin has a protective effect against COVID-19, but caution is needed in interpreting the data as larger prospective studies are required for confirmation.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

添加到收藏夹

Article Infectious Diseases

Worldwide inverse correlation between Bacille Calmette-Guerin (BCG) immunization and COVID-19 mortality

Willis X. Li

Summary: The study investigates factors contributing to different impacts of COVID-19 at the country level. Findings show a significant inverse correlation between BCG vaccination rate and COVID-19 mortality, while per capita GDP and median age positively correlate with COVID-19 mortality. Meanwhile, COVID-19 cases correlate significantly with per capita GDP and testing rates.

INFECTION (2021)

添加到收藏夹

Article Medicine, Research & Experimental

BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers

Magali Noval Rivas et al.

Summary: In this study of healthcare workers, those with a history of BCG vaccination had lower seroprevalence of anti-SARS-CoV-2 IgG and reported fewer COVID-19-related symptoms compared to those without BCG vaccination. This suggests a potential protective effect of BCG vaccination against SARS-CoV-2 infection, warranting further large-scale clinical trials for confirmation.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Editorial Material Immunology

BCG vaccine: Worrying proposal for COVID-19

Emanuel Sarinho et al.

Summary: The BCG vaccine is effective in protecting against severe tuberculosis and may offer some non-specific protection against other infectious diseases, although the duration of this protection is uncertain. Careful consideration should be given before revaccinating with BCG to avoid serious risks to patients with immunodeficiencies.

VACCINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The association of Coronavirus Disease-19 mortality and prior bacille Calmette-Guerin vaccination: a robust ecological analysis using unsupervised machine learning

Nathan A. Brooks et al.

Summary: The study found that countries with active BCG vaccination programs for the past 15 years had lower COVID-19 related mortality rates, with mortality rates increasing significantly with a higher percentage of population over 65. A higher total population and longer implementation of BCG vaccination programs were significantly associated with improved COVID-19 related mortality rates.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Immunology

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Kerry L. Hilligan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

Bacillus Calmette-Guerin Vaccine and Nonspecific Immunity

Kanak Parmar et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

COVID-19 and the human innate immune system

Joachim L. Schultze et al.

Summary: The introduction of SARS-CoV-2 into the human population has led to a significant medical and economic crisis. Innate immunity plays a central role in combating the novel virus, with variability in its components contributing to the diverse disease courses observed for COVID-19. Further research into the pathophysiological mechanisms of innate immunity is crucial for the development of diagnostic markers and therapeutic strategies targeting COVID-19.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Wilfredo F. Garcia-Beltran et al.

Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.

CELL (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Influence of malaria endemicity and tuberculosis prevalence on COVID-19 mortality

T. F. Raham

Summary: Malaria and standardized TB prevalence are statistically significant factors associated negatively with COVID-19 mortality, indicating a potentially protective effect against the disease in malaria-endemic countries.

PUBLIC HEALTH (2021)

添加到收藏夹

Letter Biotechnology & Applied Microbiology

Anticipated reduction in COVID-19 mortality due to population-wide BCG vaccination: evidence from Germany

Daniela Marin-Hernandez et al.

Summary: The BCG vaccine may have protective effects against respiratory infections and potential benefits on COVID-19 outcomes in elderly populations; differential past BCG vaccination policies between East and West Germany provide an opportunity to assess the impact of prior BCG vaccination on COVID-19; study findings support the use of a combined approach involving heterologous vaccines and non-pharmaceutical interventions to mitigate the SARS-CoV-2 pandemic.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

添加到收藏夹

Review Immunology

Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

Kelvin Kai-Wang To et al.

Summary: The lack of modern medical management and vaccines could lead to the COVID-19 pandemic reaching the levels of past deadly outbreaks like the 1894 plague and 1918-A(H1N1) influenza pandemic. The presence of multiple coronaviruses with pandemic potential in animals, coupled with environmental factors like the mixing and selling of wild mammals with poor hygiene practices in urban markets, pose a significant threat to global health. The emergence of new viruses and the challenges of mass testing, contact tracing, treatment, and potential development of vaccine-resistant virus variants highlight the importance of global preparedness in combating infectious diseases.

EMERGING MICROBES & INFECTIONS (2021)

添加到收藏夹

Article Biochemical Research Methods

In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect

Sondes Haddad-Boubaker et al.

Summary: This study investigated the potential implication of 12 vaccines in protecting against COVID-19, revealing highly similar segments in some vaccines with antigenic properties that may induce a protective effect against the virus. Specifically, segments in Hepatitis B, Tetanus, and Measles proteins were identified to have immunogenic potential against COVID-19.

BMC BIOINFORMATICS (2021)

添加到收藏夹

Article Cell Biology

Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2

Espiridion Ramos-Martinez et al.

Summary: The production of specific neutralizing antibodies by individuals plays a crucial role in reducing severe COVID-19 cases, and revaccination with BCG was found to have a positive impact on the response to the SARS-CoV-2 vaccine, leading to increased neutralizing antibody titers and serum cytokine concentrations.

CELLS (2021)

添加到收藏夹

Article Immunology

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection

Claudio Counoupas et al.

Summary: This study demonstrates the potential of a BCG-based vaccine to provide protection against major SARS-CoV-2 variants by inducing potent virus-specific immune responses. Pre-treatment with BCG:CoVac followed by a heterologous vaccine boosts SARS-CoV-2-specific antibody responses effectively neutralizing key variants.

NPJ VACCINES (2021)

添加到收藏夹

Article Urology & Nephrology

Protective role of intravesical BCG in COVID-19 severity

Hector Gallegos et al.

Summary: The study found that NMIBC patients treated with BCG instillations have a lower incidence and mortality rate of COVID-19, which could decrease the fatality rate of COVID-19. Therefore, it is recommended not to suspend BCG instillation treatment during a pandemic.

BMC UROLOGY (2021)

添加到收藏夹

Article Genetics & Heredity

IFN-γ and TNF-α drive a CXCL10+CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

Fan Zhang et al.

Summary: Through single-cell transcriptomic analysis, shared immune cell states between COVID-19 and other inflammatory diseases were identified, providing insights for immunomodulatory therapies. A specific inflammatory macrophage phenotype was found in severe COVID-19 and other inflammatory diseases, induced by co-stimulation by IFN-gamma and TNF-alpha.

GENOME MEDICINE (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Countries with high deaths due to flu and tuberculosis demonstrate lower COVID-19 mortality: roles of vaccinations

Sanmoy Pathak et al.

Summary: This global epidemiological analysis found that countries with high flu and TB death rates are negatively correlated with COVID-19 death rates, while high flu vaccination rates are positively correlated with higher COVID-19 death rates. BCG vaccination is negatively correlated with COVID-19 death rates, and countries with only BCG vaccination show delayed and lower COVID-19 deaths compared to countries with only flu vaccination.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

添加到收藏夹

Article Environmental Sciences

COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan

Wei-Ju Su et al.

Summary: The study found that BCG vaccination may not be related to COVID-19 severity in the young population, with most individuals aged 4-24 who received BCG vaccine being asymptomatic or having mild symptoms, and no deaths reported. Furthermore, the incidence of moderate and severe disease in individuals aged 25-33 without neonatal BCG vaccination records was lower compared to those with vaccination records.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

A Survey Among Italian Physicians During COVID-19 Outbreak. Could Bacillus Calmette-Guerin Vaccine Be Effective Against SARS-CoV2?

Vincenzo Patella et al.

Summary: The study aimed to evaluate the protective effect of TB vaccination against COVID-19 and found that there was no significant difference in the prevalence of COVID-19 infection between the vaccinated and unvaccinated groups. Further research is needed to confirm the protective role of BCG vaccination against COVID-19.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Immunology

Repurposing of the childhood vaccines: could we train the immune system against the SARS-CoV-2

Divakar Sharma

Summary: The article suggests repurposing childhood vaccines such as BCG, MMR, and OPV which are live attenuated vaccines with protective effects through 'trained immunity' and 'crossreactivity'. Using these vaccines in combination with available COVID-19 therapeutics and vaccines could provide a better protective effect against SARS-CoV-2 infection and its subsequent waves.

EXPERT REVIEW OF VACCINES (2021)

添加到收藏夹

Review Immunology

COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials

Wenping Gong et al.

Summary: This study reviewed the concept and mechanisms of trained immunity induced by the BCG vaccine and presented details of current BCG vaccine clinical trials. The advantages of the BCG vaccine may be essential in overcoming the challenges faced by COVID-19 vaccines.

EXPERT REVIEW OF VACCINES (2021)

添加到收藏夹

Article Infectious Diseases

The effect of BCG revaccination on all-cause mortality beyond infancy: 30-year follow-up of a population-based, double-blind, randomised placebo-controlled trial in Malawi

Judith R. Glynn et al.

Summary: The study found little evidence of any beneficial effect of BCG revaccination on all-cause mortality. The high proportion of deaths attributable to non-infectious causes beyond infancy, and the long time interval since BCG for most deaths, might obscure any benefits.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Association of the past epidemic of Mycobacterium tuberculosis with mortality and incidence of COVID-19

Kazuo Inoue et al.

Summary: This study revealed an inverse relationship between the past epidemic of tuberculosis and the impact of COVID-19, suggesting a possible mechanism underlying regional variations in COVID-19 impact. Additionally, the study found an association even after adjusting for potential confounders, indicating the potential role of latent tuberculosis infection in stimulating trained immunity against COVID-19.

PLOS ONE (2021)

添加到收藏夹

Article Immunology

Does BCG provide long-term protection against SARS-CoV-2 infection? A case-control study in Quebec, Canada

Jacques Pepin et al.

Summary: The study found that BCG vaccination does not provide long-term protection against symptomatic COVID-19 or severe forms of the disease.

VACCINE (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Effectiveness of booster BCG vaccination in preventing Covid-19 infection

Lradj Amirlak et al.

Summary: The study found that no cases of COVID-19 infection were detected among employees who received the booster BCG vaccine, compared to 18 positive cases in the unvaccinated group. This suggests the potential effectiveness of the booster BCG vaccine in preventing COVID-19 infections in a high-risk healthcare population.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

添加到收藏夹

Article Infectious Diseases

The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study

Selma Regina Penha Silva Cerqueira et al.

Summary: This study evaluated the relationship between leprosy patients and COVID-19, finding that only COVID-19-positive household contacts and diabetes mellitus were significant risk factors for COVID-19. Leprosy patients are vulnerable to COVID-19 possibly due to social and economic constraints.

PLOS NEGLECTED TROPICAL DISEASES (2021)

添加到收藏夹

Article Immunology

BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity

Peter J. Eggenhuizen et al.

Summary: The Bacillus Calmette-Guerin (BCG) vaccine can enhance T cell response to the SARS-CoV-2 virus, providing a potential mechanism for the observed protective effects against COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Effect of BCG vaccination on proinflammatory responses in elderly individuals

Nathella Pavan Kumar et al.

Summary: The study found that BCG vaccination reduced levels of various cytokines and chemokines in healthy elderly individuals, leading to decreased inflammation. This suggests the potential utility of BCG vaccination in modulating inflammatory responses and its application in COVID-19.

SCIENCE ADVANCES (2021)

添加到收藏夹

Article Infectious Diseases

Exploring the role of bacillus calmette-guerin vaccination in protection against COVID-19

Anil Chauhan et al.

Summary: The study did not find significant differences in the risk of COVID-19 between those vaccinated with BCG and those unvaccinated, but individuals with a BCG scar had a lower positivity rate for COVID-19.

INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Association of bacillus calmette guerin vaccine strains with COVID-19 morbidity and mortality - evaluation of global data

Vijaya Laxman Chaudhari et al.

Summary: The current BCG policy is associated with lower COVID-19 mortality, but the type of BCG strain used does not impact disease burden according to a global data audit.

INDIAN JOURNAL OF COMMUNITY MEDICINE (2021)

添加到收藏夹

Article Immunology

Severity of COVID-19 in bacillus Calmette-Guerin vaccinated population

Iffat Khanum et al.

Summary: This study found no association between prior BCG vaccination and severity of COVID-19, but it could potentially have a protective role in already infected patients with a low mortality rate.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2021)

添加到收藏夹

Review Medicine, General & Internal

Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?

Zaixing Jia et al.

Summary: SARS-CoV-2 has caused a global pandemic since its discovery, leading to the emergence of variants with common N501Y mutations that may impact viral fitness and transmission, although the effects on COVID-19 vaccines remain unknown.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

添加到收藏夹

Article Immunology

A possible protective role for Bacillus Calmette-Guerin therapy in urinary bladder cancer in the era of COVID-19: a brief report

Solmaz Ohadian Moghadam et al.

Summary: This study examined SARS-CoV-2 infection in bladder cancer patients with a history of BCG therapy, finding no significant association between BCG therapy and COVID-19. However, patients who had recently received BCG therapy had a lower infection rate compared to those who had received therapy more than a year ago.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Association between live childhood vaccines and COVID-19 outcomes: a national-level analysis

Chikara Ogimi et al.

Summary: Higher coverage of childhood live vaccines is associated with lower COVID-19 death rates, but this association weakens when accounting for differences in healthcare quality and access indices, especially HAQI. Vaccine coverage variables are strongly correlated with COVID-19 testing rates, HAQI, and life expectancy, suggesting potential confounding factors impacting population-level associations.

EPIDEMIOLOGY AND INFECTION (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Association between COVID-19 morbidity and mortality rates and BCG vaccination policies in OECD countries

Yuki Senoo et al.

Summary: The study compared the effect of national BCG vaccination policy on COVID-19 in OECD countries, finding that countries with BCG vaccination policies have lower morbidity and mortality rates compared to those without, indicating a potential protective effect of BCG vaccination against COVID-19.

JOURNAL OF INFECTION PREVENTION (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Is BCG associated with reduced incidence of COVID-19? A meta-regression of global data from 160 countries

Melvin Joy et al.

Summary: Global research is focused on finding a vaccine to stop COVID-19, with the BCG vaccine gaining attention. This study analyzed data from 160 countries and found an association between BCG vaccine coverage and incidence of COVID-19, with lower infection rates when coverage is over 70%.

CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19

Pouria Mosaddeghi et al.

Summary: No proven remedy for COVID-19 has been identified yet. Boosting immune responses may be beneficial as impaired immunity activation in some patients leads to high mortalities. Co-administration of BCG vaccine with interferon-alpha/-beta or influenza vaccine is suggested as a potential strategy to overcome its shortcomings and enhance immune defenses against COVID-19. Further studies are recommended to assess the outcomes of such interventions and potential adverse effects.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Can BCG vaccine protect against COVID-19 via trained immunity and tolerogenesis?

Preetam Basak et al.

Summary: BCG vaccination has shown a potential positive correlation to reduce COVID-19 mortality by inducing trained immunity and tolerogenicity. Further research on BCG-mediated immunoprotection, particularly in vulnerable populations, may be crucial in combating the SARS-CoV-2 pandemic.

BIOESSAYS (2021)

添加到收藏夹

Review Respiratory System

COVID-19 Death and BCG Vaccination Programs Worldwide

Feras J. Jirjees et al.

Summary: Clinical trials are investigating the protective effect of the BCG vaccine against death in healthcare providers working with COVID-19 patients. Studies have shown that countries with a national BCG vaccination policy have significantly lower COVID-19 death rates compared to those without such a policy. Establishing a BCG vaccination policy early is crucial in reducing COVID-19 and tuberculosis death cases.

TUBERCULOSIS AND RESPIRATORY DISEASES (2021)

添加到收藏夹

Review Medicine, General & Internal

Benefits of BCG-induced metabolic switch from oxidative phosphorylation to aerobic glycolysis in autoimmune and nervous system diseases

D. L. Faustman

JOURNAL OF INTERNAL MEDICINE (2020)

添加到收藏夹

Letter Allergy

Is global BCG vaccination-induced trained immunity relevant to the progression of SARS-CoV-2 pandemic?

Mayda Gursel et al.

ALLERGY (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID-19

Bharat Damle et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2020)

添加到收藏夹

Letter Medicine, General & Internal

SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults

Uri Hamiel et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Article Infectious Diseases

Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS or COVID‐19: initial assessment

Nathan Ford et al.

Journal of the International AIDS Society (2020)

添加到收藏夹

Article Immunology

Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2?

Camila Covian et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Microbiology

Repurposing Didanosine as a Potential Treatment for COVID-19 Using Single-Cell RNA Sequencing Data

Fadhl M. Alakwaa

MSYSTEMS (2020)

添加到收藏夹

Article Pathology

Strong homology between SARS-CoV-2 envelope protein and a Mycobacterium sp. antigen allows rapid diagnosis of Mycobacterial infections and may provide specific anti-SARS-CoV-2 immunity via the BCG vaccine

Gerard Nuovo et al.

ANNALS OF DIAGNOSTIC PATHOLOGY (2020)

添加到收藏夹

Letter Pediatrics

BCG Vaccination Policy and Protection Against COVID-19

Jitendra Meena et al.

INDIAN JOURNAL OF PEDIATRICS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Mandated Bacillus Calmette-Guerin (BCG) vaccination predicts flattened curves for the spread of COVID-19

Martha K. Berg et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Article Infectious Diseases

Impact of Routine Infant BCG Vaccination on COVID-19

Masako Kinoshita et al.

JOURNAL OF INFECTION (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

BCG vaccination early in life does not improve COVID-19 outcome of elderly populations, based on nationally reported data

T. M. Wassenaar et al.

LETTERS IN APPLIED MICROBIOLOGY (2020)

添加到收藏夹

Letter Oncology

Regional BCG vaccination policy in former East- and West Germany may impact on both severity of SARS-CoV-2 and incidence of childhood leukemia

Julia Hauer et al.

LEUKEMIA (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

Evangelos J. Giamarellos-Bourboulis et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

Luis E. Escobar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Editorial Material Health Care Sciences & Services

COVID-19: Complexity and the Black Swan

Andrew S. Valeras

FAMILIES SYSTEMS & HEALTH (2020)

添加到收藏夹

Article Environmental Sciences

BCG Vaccination and Mortality of COVID-19 across 173 Countries: An Ecological Study

Mitsuyoshi Urashima et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

添加到收藏夹

Article Medicine, Research & Experimental

BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner

Valerie A. C. M. Koeken et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

添加到收藏夹

Editorial Material Medicine, Research & Experimental

Antituberculosis BCG vaccination: more reasons for varying innate and adaptive immune responses

S. Prentice et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

BCG epidemiology supports its protection against COVID-19? A word of caution

Reka Szigeti et al.

PLOS ONE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Global impact of environmental temperature and BCG vaccination coverage on the transmissibility and fatality rate of COVID-19

Amit Kumar et al.

PLOS ONE (2020)

添加到收藏夹

Letter Multidisciplinary Sciences

Lack of evidence for BCG vaccine protection from severe COVID-19

Cecilia S. Lindestam Arlehamn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Immunology

BCG vaccine may generate cross-reactive T cells against SARS-CoV-2: In silico analyses and a hypothesis

Yusuke Tomita et al.

VACCINE (2020)

添加到收藏夹

Article

Is the tuberculosis vaccine BCG an alternative weapon for developing countries to defeat COVID-19?

Wenping Gong et al.

Indian Journal of Tuberculosis (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

BCG vaccine: a hope to control COVID-19 pandemic amid crisis

Yashpal Singh Malik et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

添加到收藏夹

Review Public, Environmental & Occupational Health

Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications

Andrew T. Levin et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

On the relationship between BCG coverage and national COVID-19 outcome: could 'heterologous' herd immunity explain why some countries are better off?

M. Lerm

JOURNAL OF INTERNAL MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19

Lucy Chimoyi et al.

PLOS ONE (2020)

添加到收藏夹

Article Immunology

Identification of similar epitopes between severe acute respiratory syndrome coronavirus-2 and Bacillus Calmette-Guerin: potential for cross-reactive adaptive immunity

Szabolcs Urban et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

添加到收藏夹

Article Microbiology

Trained immunity from Mycobacterium spp. exposure or BCG vaccination and COVID-19 outcomes

Samer Singh et al.

PLOS PATHOGENS (2020)

添加到收藏夹

Article Immunology

Bacillus Calmette-Guerin (BCG) vaccine generates immunoregulatory cells in the cervical lymph nodes in guinea pigs injected intra dermally

Souzan Vergkizi et al.

VACCINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analyses

Janine Hensel et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Immunology

Current national policies for infant universal bacille Calmette-Guerin vaccination were associated with lower mortality from coronavirus disease 2019

Risa Ebina-Shibuya et al.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2020)

添加到收藏夹

Article Cell Biology

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

Simone J. C. F. M. Moorlag et al.

CELL REPORTS MEDICINE (2020)

添加到收藏夹

Article Infectious Diseases

Differential effects of BCG vaccine on immune responses induced by vi polysaccharide typhoid fever vaccination: an explorative randomized trial

Bastiaan A. Blok et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

Bacillus Calmette-Guerin vaccination and clinical characteristics and outcomes of COVID-19 in Rhode Island, United States: a cohort study

C-H. Weng et al.

EPIDEMIOLOGY AND INFECTION (2020)

添加到收藏夹

Review Infectious Diseases

Non-specific effects of BCG vaccine on viral infections

S. J. C. F. M. Moorlag et al.

CLINICAL MICROBIOLOGY AND INFECTION (2019)

添加到收藏夹

Review Infectious Diseases

Non-specific effects of BCG in protozoal infections: tegumentary leishmaniasis and malaria

J. C. dos Santos et al.

CLINICAL MICROBIOLOGY AND INFECTION (2019)

添加到收藏夹

Article Medicine, General & Internal

Association between Bacillus Calmette-Guerin vaccination and lymphoma: a population-based birth cohort study

C. Salmon et al.

JOURNAL OF INTERNAL MEDICINE (2019)

添加到收藏夹

Article Neurosciences

Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

Fiona Tea et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

添加到收藏夹

Article Medicine, General & Internal

Association of BCG Vaccination in Childhood With Subsequent Cancer Diagnoses A 60-Year Follow-up of a Clinical Trial

Nicholas T. Usher et al.

JAMA NETWORK OPEN (2019)

添加到收藏夹

Article Dermatology

Bacillus Calmette-Guerin immunotherapy for Recurrent Multiple Warts: An Open-Label Uncontrolled Study

Avtar Kishan Jaisinghani et al.

INDIAN JOURNAL OF DERMATOLOGY (2019)

添加到收藏夹

Article Microbiology

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

Rob J. W. Arts et al.

CELL HOST & MICROBE (2018)

添加到收藏夹

Review Immunology

Non-specific effects of vaccines: Current evidence and potential implications

L. C. J. de Bree et al.

SEMINARS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Adjuvant Effect of Bacille Calmette-Guerin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn

Annette Scheid et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations

Willem M. Kuhtreiber et al.

NPJ VACCINES (2018)

添加到收藏夹

Review Microbiology

Heterologous effects of infant BCG vaccination: potential mechanisms of immunity

Egle Butkeviciute et al.

FUTURE MICROBIOLOGY (2018)

添加到收藏夹

Review Immunology

Bridging the gap between vaccination with Bacille Calmette-Guerin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis

Giovanni Ristori et al.

CURRENT OPINION IN IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

BCG and protection against inflammatory and auto-immune diseases

Magdalena Kowalewicz-Kulbat et al.

EXPERT REVIEW OF VACCINES (2017)

添加到收藏夹

Article Dermatology

Immunotherapy in viral warts with intradermal Bacillus Calmette-Guerin vaccine versus intradermal tuberculin purified protein derivative: A double-blind, randomized controlled trial comparing effectiveness and safety in a tertiary care center in Eastern India

Indrashis Podder et al.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia

Sanjay Mukherjee et al.

PLOS ONE (2017)

添加到收藏夹

Article Dermatology

BCG vaccine for immunotherapy in warts: is it really safe in a tuberculosis endemic area?

Deepashree Daulatabad et al.

DERMATOLOGIC THERAPY (2016)

添加到收藏夹

Article Immunology

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

Claudio Procaccini et al.

IMMUNITY (2016)

添加到收藏夹

Article Infectious Diseases

Duration of BCG protection against tuberculosis and change in effectiveness with time since vaccination in Norway: a retrospective population-based cohort study

Patrick Nguipdop-Djomo et al.

LANCET INFECTIOUS DISEASES (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Bacillus Calmette-Guerin Confers Neuroprotection in a Murine Model of Japanese Encephalitis

Sahil Kulkarni et al.

NEUROIMMUNOMODULATION (2016)

添加到收藏夹

Review Multidisciplinary Sciences

Trained immunity: A program of innate immune memory in health and disease

Mihai G. Netea et al.

SCIENCE (2016)

添加到收藏夹

Article Immunology

Heterologous vaccine effects

Mitra Saadatian-Elahi et al.

VACCINE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Mycobacteria-responsive sonic hedgehog signaling mediates programmed death-ligand 1-and prostaglandin E2-induced regulatory T cell expansion

Sahana Holla et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Immunology

Harnessing the beneficial heterologous effects of vaccination

Helen S. Goodridge et al.

NATURE REVIEWS IMMUNOLOGY (2016)

添加到收藏夹

Article Immunology

Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis

Maria Jose de Castro et al.

CLINICAL INFECTIOUS DISEASES (2015)

添加到收藏夹

Article Immunology

BCG Vaccination Enhances the Immunogenicity of Subsequent Influenza Vaccination in Healthy Volunteers: A Randomized, Placebo-Controlled Pilot Study

Jenneke Leentjens et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

添加到收藏夹

Article Immunology

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

Veronica De Rosa et al.

NATURE IMMUNOLOGY (2015)

添加到收藏夹

Article Immunology

Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials

Punam Mangtani et al.

CLINICAL INFECTIOUS DISEASES (2014)

添加到收藏夹

Article Immunology

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

Johanneke Kleinnijenhuis et al.

JOURNAL OF INNATE IMMUNITY (2014)

添加到收藏夹

Article Parasitology

A Novel Recombinant BCG Vaccine Encoding Eimeria tenella Rhomboid and Chicken IL-2 Induces Protective Immunity Against Coccidiosis

Qiuyue Wang et al.

KOREAN JOURNAL OF PARASITOLOGY (2014)

添加到收藏夹

Editorial Material Pharmacology & Pharmacy

Nonspecific Effects of Vaccines and the Reduction of Mortality in Children

Frank Shann

CLINICAL THERAPEUTICS (2013)

添加到收藏夹

Article Immunology

CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8+CD39+regulatory T cells

Mardi C. Boer et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

添加到收藏夹

Article Parasitology

Eimeria maxima: efficacy of recombinant Mycobacterium bovis BCG expressing apical membrane antigen1 against homologous infection

Wen-Chao Li et al.

PARASITOLOGY RESEARCH (2013)

添加到收藏夹

Article Dermatology

Treatment of Common and Plane Warts in Children with Topical Viable Bacillus Calmette-Guerin

Ahmed Salem et al.

PEDIATRIC DERMATOLOGY (2013)

添加到收藏夹

Review Immunology

A small jab - a big effect: nonspecific immunomodulation by vaccines

Christine S. Benn et al.

TRENDS IN IMMUNOLOGY (2013)

添加到收藏夹

Article Immunology

Non-specific effect of Bacille Calmette-Guerin vaccine on the immune response to routine immunisations

Nicole Ritz et al.

VACCINE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes

Denise L. Faustman et al.

PLOS ONE (2012)

添加到收藏夹

Article Immunology

SMALL RANDOMIZED TRIAL AMONG LOW-BIRTH-WEIGHT CHILDREN RECEIVING BACILLUS CALMETTE-GUERIN VACCINATION AT FIRST HEALTH CENTER CONTACT

Sofie Biering-Sorensen et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Article Immunology

Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?

Peter Aaby et al.

JOURNAL OF INFECTIOUS DISEASES (2011)

添加到收藏夹

Article Immunology

Inflammasomes and Anti-Viral Immunity

Vijay A. K. Rathinam et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2010)

添加到收藏夹

Article Allergy

Neonatal BCG vaccination induces IL-10 production by CD4+CD25+T cells

Tunc Akkoc et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2010)

添加到收藏夹

Article Virology

CD4 T-Cell-Mediated Heterologous Immunity between Mycobacteria and Poxviruses

Keisha S. Mathurin et al.

JOURNAL OF VIROLOGY (2009)

添加到收藏夹

Article Public, Environmental & Occupational Health

BCG vaccination scar associated with better childhood survival in Guinea-Bissau

A Roth et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2005)

添加到收藏夹

Article Urology & Nephrology

Application of viable bacille Calmette-Guerin topically as a potential therapeutic modality in condylomata acuminata: A placebo-controlled study

B Metawea et al.

UROLOGY (2005)

添加到收藏夹

Article Immunology

Acute lower respiratory tract infections and respiratory syncytial virus in infants in Guinea-Bissau: a beneficial effect of BCG vaccination for girls - Community based case-control study

LG Stensballe et al.

VACCINE (2005)

添加到收藏夹

Article Immunology

Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen

RE Berg et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

添加到收藏夹

Article Immunology

BCG scar and positive tuberculin reaction associated with reduced child mortality in West Africa -: A non-specific beneficial effect of BCG?

ML Garly et al.

VACCINE (2003)

添加到收藏夹

Article Urology & Nephrology

Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: A meta-analysis of the published results of randomized clinical trials

RJ Sylvester et al.

JOURNAL OF UROLOGY (2002)

添加到收藏夹

Article Immunology

Influence of Mycobacterium bovis bacillus Calmette-Guerin on antibody and cytokine responses to human neonatal vaccination

MOC Ota et al.

JOURNAL OF IMMUNOLOGY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.