BioMOF-Mn: An Antimicrobial Agent and an Efficient Nanocatalyst for Domino One-Pot Preparation of Xanthene Derivatives

In this paper, a new Mn-based metal-organic framework [UoB-6] was obtained via a one-step ultrasonic irradiation method with the ligand (H(2)bdda: 4,4'-(1,4-phenylenebis (azaneylylidene)) bis (methaneylylidene)) dibenzoic acid. The structural integrity of the synthesized BioMOF-Mn was corroborated by FT-IR, EDX, ICP, XRD, TEM, DLS, FESEM, and BET-BJH analyses. The aerobic oxidative domino reaction of benzyl alcohols or aldehydes with dimedone derivatives was performed in the presence of the UoB-6 catalyst to produce xanthene derivatives in good yields. Hot filtration and Hg poisoning tests proved the heterogeneous nature of the catalyst. Novel synthesized xanthene-based bis-aldehydes were introduced as potent HDAC1 inhibitors according to molecular docking calculations. Finally, the inhibitory activities of Mn-MOF nanoparticles were evaluated on Escherichia coli and Candida albicans. The MIC, MBC, and MFC values were determined from 2048 to 4096 mu g & BULL;mL-1 according to antimicrobial susceptibility testing methods. The inhibitory effects of antimicrobial agents can be exacerbated when loaded on BioMOFs.

Automated summary

In this study, a new Mn-based metal-organic framework [UoB-6] was successfully synthesized, and its structure was confirmed by various analysis methods. The aerobic oxidative domino reaction using UoB-6 catalyst yielded xanthene derivatives in good yields. Molecular docking calculations revealed that the newly synthesized xanthene-based bis-aldehydes showed potent HDAC1 inhibitory activity. Additionally, the inhibitory effects of Mn-MOF nanoparticles on Escherichia coli and Candida albicans were evaluated.