4.5 Review

Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis

期刊

INFLAMMATION RESEARCH
卷 71, 期 7-8, 页码 785-795

出版社

SPRINGER BASEL AG
DOI: 10.1007/s00011-022-01595-x

关键词

IRGM; Autophagy; Xenophagy; Inflammation; Cancer; Immunity

资金

  1. CAUL
  2. Cancer Institute NSW Early Career Fellowship [2019/ECF1082]
  3. UNSW Scientia Fellowship

向作者/读者索取更多资源

IRGM plays a crucial role in regulating autophagy and inflammation, impacting inflammatory diseases and cancer development. Its polymorphisms are functionally relevant to autophagic and inflammatory responses.
The human immunity-related GTPase M (IRGM) is a GTP-binding protein that regulates selective autophagy including xenophagy and mitophagy. IRGM impacts autophagy by (1) affecting mitochondrial fusion and fission, (2) promoting the co-assembly of ULK1 and Beclin 1, (3) enhancing Beclin 1 interacting partners (AMBRA1, ATG14L1, and UVRAG), (4) interacting with other key proteins (ATG16L1, p62, NOD2, cGAS, TLR3, and RIG-I), and (5) regulating lysosomal biogenesis. IRGM also negatively regulates NLRP3 inflammasome formation and therefore, maturation of the important pro-inflammatory cytokine IL-1 beta, impacting inflammation and pyroptosis. Ultimately, this affords protection against chronic inflammatory diseases. Importantly, ten IRGM polymorphisms (rs4859843, rs4859846, rs4958842, rs4958847, rs1000113, rs10051924, rs10065172, rs11747270, rs13361189, and rs72553867) have been associated with human inflammatory disorders including cancer, which suggests that these genetic variants are functionally relevant to the autophagic and inflammatory responses. The current review contextualizes IRGM, its modulation of autophagy, and inflammation, and emphasizes the role of IRGM as a cross point of immunity and tumorigenesis.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据