Asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in adults is uncommon using rigorous symptom characterization and follow-up in an acute-care adult hospital outbreak

Article Immunology

Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers

Emilie Goguet et al.

Summary: This study aimed to determine the frequency of asymptomatic SARS-CoV-2 infections in a cohort of healthcare workers. The results suggest that asymptomatic infections in unvaccinated, immunocompetent adults are less common than previously reported.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Review Immunology

A systematic review of asymptomatic infections with COVID-19

Zhiru Gao et al.

Summary: Since the outbreak of COVID-19 at the end of December 2019, it has caused significant harm and challenges to over 200 countries and regions worldwide. Many patients with COVID-19 are asymptomatic or have only mild symptoms, yet they can still spread the virus, making screening for asymptomatic infections difficult and complicating national prevention and control efforts.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2021)

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Article Infectious Diseases

Towards an accurate and systematic characterisation of persistently asymptomatic infection with SARS-CoV-2

Eric A. Meyerowitz et al.

Summary: The transmission of SARS-CoV-2 from asymptomatic individuals contributes to pandemic spread, but accurately estimating this proportion is hindered by methodological issues like incomplete symptom assessment and inadequate follow-up. Recommendations regarding definitions, detection, documentation, and follow-up are provided to improve the identification and evaluation of people with persistently asymptomatic SARS-CoV-2 infection and their contacts. Accurate characterization of the persistently asymptomatic fraction of infected individuals could shed light on COVID-19 pathogenesis and transmission dynamics, and inform public health responses.

LANCET INFECTIOUS DISEASES (2021)

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Letter Infectious Diseases