期刊
INFECTION AND IMMUNITY
卷 90, 期 7, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/iai.00127-22
关键词
Cryptosporidiosis; animal models; interferon gamma; Cryptosporidium tyzzeri; Cryptosporidium parvum; vaccine evaluation
资金
- National Institute of Allergy and Infectious Diseases [NIH R21AI149046, R21AI144521]
Cryptosporidiosis has been identified as a major cause of morbidity and mortality in children with diarrhea in low-income countries. One of the main challenges in developing vaccines to control this disease is the lack of well-characterized immunocompetent rodent models. In this study, two mouse models were optimized and compared for vaccine evaluation, providing valuable references for future research.
Cryptosporidiosis was shown a decade ago to be a major contributor to morbidity and mortality of diarrheal disease in children in low-income countries. A serious obstacle to develop and evaluate immunogens and vaccines to control this disease is the lack of well-characterized immunocompetent rodent models. Here, we optimized and compared two mouse models for the evaluation of vaccines: the Cryptosporidium tyzzeri model, which is convenient for screening large numbers of potential mixtures of immunogens, and the Cryptosporidium parvum-infected mouse pretreated with interferon gamma-neutralizing monoclonal antibody.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据