期刊
INFECTION
卷 51, 期 1, 页码 129-136出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s15010-022-01853-4
关键词
Bacteremia; COVID-19; SOFA score; Charlson score; Immunosuppressive therapy
The development of bloodstream infections (BSIs) in COVID-19 patients admitted to the ICU is associated with a higher SOFA score, longer duration of intubation, longer ICU stay, and higher mortality. However, immunosuppressive therapy like steroids and tocilizumab does not increase the risk of bacteremia.
Purpose This multicenter observational study was done to evaluate risk factors related to the development of BSI in patients admitted to ICU for COVID-19. Methods All patients with COVID-19 admitted in two COVID-19 dedicated ICUs in two different hospital between 02-2020 and 02-2021 were recruited. Result 537 patients were included of whom 265 (49.3%) experienced at least one BSI. Patients who developed bacteremia had a higher SOFA score [10 (8-12) vs 9 (7-10), p < 0.001], had been intubated more frequently [95.8% vs 75%, p < 0.001] and for a median longer time [16 days (9-25) vs 8 days (5-14), p < 0.001]. Patients with BSI had a median longer ICU stay [18 days (12-31.5) vs 9 days (5-15), p < 0.001] and higher mortality [54% vs 42.3%, p < 0.001] than those who did not develop it. Development of BSI resulted in a higher SOFA score [aHR 1.08 (95% CI 1.03-1.12)] and a higher Charlson score [csAHR 1.15 (95% CI 1.05-1.25)]. Conclusion A high SOFA score and a high Charlson score resulted associated with BSI's development. Conversely, immunosuppressive therapy like steroids and tocilizumab, has no role in increasing the risk of bacteremia.
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