4.6 Article

Thermal Instability of Choline Chloride-Based Deep Eutectic Solvents and Its Influence on Their Toxicity-Important Limitations of DESs as Sustainable Materials

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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
卷 61, 期 30, 页码 11288-11300

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AMER CHEMICAL SOC
DOI: 10.1021/acs.iecr.2c01898

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  1. National Science Centre, Warsaw, Poland [UMO-2018/30/E/ST8/00642]

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The stability, reusability, and biocompatibility of deep eutectic solvents (DESs) play an important role in their applications. The study investigated the long-term stability of three choline chloride (ChCl)-based DESs formed using glucose, malonic acid, and urea as hydrogen bond donors. It was found that ChCl:urea DES showed high thermal stability and low toxicity to bacteria, making it a green solvent. However, ChCl:glucose DES decomposed at elevated temperatures and ChCl:malonic DES showed thermal instability and high toxicity compared to other DESs.
Deep eutectic solvents (DESs) have become a hot topic in many branches of science due to their remarkable properties. They have been studied in a wide variety of applications. In particular, choline chloride (ChCl)-based DESs are one of the most commonly used representatives of these fluids. Nevertheless, in order to apply DESs in some fields, it is essential to guarantee their stability, reusability, and biocompatibility. In this context, the long-term stability of three ChCI-based DESs formed using glucose, malonic acid, and urea as hydrogen bond donors was investigated. Furthermore, the possible formation of toxic by-products during long-term heating was evaluated for the first time, and toxicological studies using three bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) were performed. ChCl:urea DES revealed a high long-term thermal stability and was also found to be less toxic to the bacteria and thus can be considered as green solvent. ChCl:glucose DES started to decompose as a result of possible caramelization at 100 degrees C, and decomposition was further promoted at more elevated temperatures. Degradation of this DES did not affect greatly the toxicity toward bacteria, and low antibacterial properties were observed. The applicability of ChCI:malonic DES is not recommended as this DES was shown to be thermally unstable due to esterification and decomposition of malonic acid into acetic acid and carbon dioxide. Moreover, high toxicity of this DES in comparison to other DESs assayed in this study was reported.

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