4.4 Article

Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Respiratory System

The synergistic Reduning and cefmetazole sodium treatment of severe pneumonia is mediated by the AhR-Src-STAT3 pathway

Shanjun Luo et al.

Summary: RDN can synergistically enhance the effect of cefmetazole sodium treatment in severe pneumonia by increasing the expression level of IL-10 mediated through the AhR-Src-STAT3 pathway, driving macrophage polarization, and attenuating the cytokine storm to control inflammation.

JOURNAL OF THORACIC DISEASE (2022)

Article Cell Biology

Triptolide decreases tumor-associated macrophages infiltration and M2 polarization to remodel colon cancer immune microenvironment via inhibiting tumor-derived CXCL12

Xuan Jiang et al.

Summary: Triptolide treatment shows therapeutic effects against colon cancer both in vivo and in vitro by inhibiting cancer cell proliferation and inducing apoptosis. In the tumor immune microenvironment, triptolide treatment reduces tumor-associated macrophage infiltration by downregulating tumor-derived CXCL12 expression, thus remodeling the immune microenvironment. Triptolide also inhibits the polarization of colon cancer cells to an anti-inflammatory state, and decreases the migration of cancer cells by reducing vascular endothelial growth factor expression.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Cell Biology

Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest

Qiang Chen et al.

Summary: This study found that TPL improved neurobehavioral functions, reduced neuroinflammation and oxidative stress, and inhibited microglial activation and cell death in DHCA rats. Additionally, TPL activated the Nrf2 pathway and suppressed NF-kappa B activity, suggesting potential mechanisms for its neuroprotective effects.

AGING-US (2021)

Article Neurosciences

PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury

Sisi Li et al.

Summary: The study indicated that PLXNA2 knockdown accelerated the recovery of motor function and cognitive ability in rats with MCAO/R, inhibited proinflammatory cytokine release and promoted anti-inflammatory cytokine release. The mTOR/STAT3 pathway was involved in PLXNA2 regulated microglia polarization.

EXPERIMENTAL NEUROLOGY (2021)

Editorial Material Biochemistry & Molecular Biology

From macrophage biology to macrophage-based cellular immunotherapies

Elvira Mass et al.

GENE THERAPY (2021)

Article Plant Sciences

Pinoresinol diglucoside (PDG) attenuates cardiac hypertrophy via AKT/mTOR/NF- K B signaling in pressure overload-induced rats

Yusha Chen et al.

Summary: Pinoresinol diglucoside (PDG) prevents cardiac hypertrophy and inflammation caused by pressure overload, protecting cardiac tissues from damage. PDG has inhibitory effects on cardiac hypertrophy and inflammatory responses, potentially exerting its protective effects by inhibiting the AKT/mTOR/NF-kB signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Triptolide: reflections on two decades of research and prospects for the future

Lu Tong et al.

Summary: This review summarizes the progress in material sourcing, molecular mechanisms, clinical progress, and new drug design strategies of triptolide over the past two decades, and discusses some prospects for the future development of triptolide.

NATURAL PRODUCT REPORTS (2021)

Review Biochemistry & Molecular Biology

Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects

Cong-ying Song et al.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2020)

Review Pharmacology & Pharmacy

Macrophage M1/M2 polarization

Chen Yunna et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Medicine, Research & Experimental

Triptolide attenuates laser-induced choroidal neovascularization via M2 macrophage in a mouse model

Kunbei Lai et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Immunology

M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds

Youhan Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Article Immunology

Triptolide ameliorates lupus via the induction of miR-125a-5p-mediating Treg upregulation

Xia Zhao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Article Integrative & Complementary Medicine

Triptolide attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of NF-κB pathway

Chundong Song et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Article Surgery

Inflammatory Bowel Disease Presentation and Diagnosis

Sean Flynn et al.

SURGICAL CLINICS OF NORTH AMERICA (2019)

Review Immunology

Implications of macrophage polarization in autoimmunity

Samanta C. Funes et al.

IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Role of Human Macrophage Polarization in Inflammation during Infectious Diseases

Chiraz Atri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Medicine, General & Internal

Management of inflammatory bowel disease

Emily K. Wright et al.

MEDICAL JOURNAL OF AUSTRALIA (2018)

Review Immunology

Chemokine-Induced Macrophage Polarization in Inflammatory Conditions

Pieter Ruytinx et al.

FRONTIERS IN IMMUNOLOGY (2018)

Editorial Material Multidisciplinary Sciences

Inflammatory bowel disease

Richard Hodson

NATURE (2016)

Article Pharmacology & Pharmacy

Safety Profiles of Tripterygium wilfordii Hook F: A Systematic Review and Meta-Analysis

Chi Zhang et al.

FRONTIERS IN PHARMACOLOGY (2016)

Review Immunology

Anatomy of a discovery: M1 and M2 macrophages

Charles Dudley Mills

FRONTIERS IN IMMUNOLOGY (2015)