4.5 Article

A brief history of epigenetics

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IMMUNOLOGY LETTERS
卷 249, 期 -, 页码 1-4

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DOI: 10.1016/j.imlet.2022.08.001

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Epigenetics

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In the past 70 years, the study of epigenetics has transitioned from being a research curiosity to being one of the most hyped biological concepts. Today, the modulation of epigenetics through behavioral changes is promoted as a cure for diseases. The concept that environmental influences can cause stable and heritable changes in gene expression has been enthusiastically embraced in the field of medical biology.
Over the past 70 years, the study of epigenetics has evolved from a research curiosity for outsiders to one of the most hyped biological concepts. While the pioneers of epigenetic research were met with disbelief when they described phenomena that did not follow the normal Mendelian laws of inheritance, the popular media today praises the modulation of epigenetics through behavioral changes as a cure for diseases. The concept that environmental influences can cause stable, heritable changes in gene expression has been embraced with such enthusiasm that the study of epigenetics has found its place in virtually every medical biology field. Because of the somewhat inflationary way in which the word epigenetics is used nowadays, it is all the more important to clarify definitions and terms before talking about epigenetic studies.

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