DCs unchained: Whetting dendritic-cell appetite boosts wound healing

Article Multidisciplinary Sciences

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

Sophia Maschalidi et al.

Summary: SLC7A11 acts as a negative regulator of efferocytosis, inhibiting its function can accelerate wound healing; it has important implications for wound management in diabetes.

NATURE (2022)

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Article Immunology

A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15

Andreas Patsalos et al.

Summary: Regenerative inflammation in skeletal muscle drives macrophage specification through a regeneration-promoting program. The orchestrated sequence of events involves multiple cell types and temporarily controlled phenotype switches of infiltrating macrophages, transitioning from pro-inflammatory to tissue repair phenotypes through the production of growth factors. The transcriptional identity of repair-macrophages develops through specialized factors like GDF-15, which coordinates proper tissue repair by acting on both myoblasts and muscle-infiltrating myeloid cells.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Review Immunology

Determining the effector response to cell death

Carla V. Rothlin et al.

Summary: Cell death is closely associated with immune responses, can be triggered by pathogens or injuries, and is followed by tissue renewal and repair processes initiated by innate immune cells. Recognizing dead cells can lead to various effector responses, depending on the cell's signals, environmental context, and the specific efferocyte involved.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Cell Biology