Of mice, men, women, and cancer

The prevalence and severity of cancers in non-reproductive tissues are greater in males than females, but the sex-specific factors contributing to this remain ill described. In this issue of Immunity, Yang et al. (2022) un-cover a mechanism of androgen signaling leading to an exhausted, terminally differentiated CD8(+) T cell phenotype in male mice.

Automated summary

The prevalence and severity of cancers in non-reproductive tissues are higher in males than females, but the sex-specific factors contributing to this remain poorly understood. In this study, Yang et al. (2022) reveal a mechanism of androgen signaling that leads to an exhausted, terminally differentiated CD8(+) T cell phenotype in male mice.