期刊
IEEE SENSORS JOURNAL
卷 22, 期 12, 页码 11328-11335出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2021.3133716
关键词
Biomedical circuit; electrical stimulation; low-power electronic; analog spike detection
资金
- German Research Foundation (DFG) [GR3328/4-3]
The aim of this research is to investigate low-power circuit concepts for the hardware implementation of an adaptively controlled stimulator for future retinal implants. The paper presents the implementation of an analog spike detection circuit to detect spikes from extracellular recordings and to perform electrode individual firing-rate measurements in a spatially high-density electrode array.
The aim of this research is to investigate low-power circuit concepts for the hardware implementation of an adaptively controlled stimulator for future retinal implants. For this specific application purpose, the circuit complexity must be low, while at the same time the functionality is extended. This paper presents the implementation of an analog spike detection circuit to detect spikes from extracellular recordings and to perform electrode individual firing-rate measurements in a spatially high-density electrode array, which has a reduced circuit complexity compared to the widely-used nonlinear energy operator (NEO) and allows stronger suppression of local oscillations following the retinal remodeling. The module is verified by emulating extracellular activities using the Hodgkin-Huxley model. This recording-unit is integrated into an eight-channel closed-loop-neurostimulator prototype. It dissipates 11.4 mu W and requires an area of 0.066 mm(2) by using a 350 nm CMOS process.
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