4.5 Article

Comparison and predictors of chronic migraine vs. new daily persistent headache presenting with a chronic migraine phenotype

期刊

HEADACHE
卷 62, 期 7, 页码 828-838

出版社

WILEY
DOI: 10.1111/head.14362

关键词

chronic migraine; medication overuse headache; new daily persistent headache

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This study compared the clinical phenotype of chronic migraine (CM) patients to patients with the chronic migraine subtype of new daily persistent headache (NDPH-CM). The UK cohort showed that CM patients had an earlier age of first headache onset, more associated migrainous symptoms, and a higher prevalence of a family history of headache compared to NDPH-CM patients. No differences were found in the US cohort. Osmophobia and older age at presentation were negative predictors of NDPH-CM.
Objective To compare the clinical phenotype of patients with chronic migraine (CM) to patients with new daily persistent headache of the chronic migraine subtype (NDPH-CM). Methods A study was conducted of CM (n = 257) and NDPH-CM (n = 76) from a tertiary headache center in the UK, and in the US of patients with daily CM (n = 60) and NDPH-CM (n = 22). Results From the UK cohort, the age of first headache onset was lower in CM (mean +/- SD: 16 +/- 12 years) than in NDPH-CM (mean +/- SD: 23 +/- 14 years; p < 0.001). There was a greater number of associated migrainous symptoms in CM compared to NDPH-CM (median and interquartile range: 6, 5-8 vs. 5, 4-7; p < 0.001). A family history of headache was more common in CM compared to NDPH-CM (82%, 202/248, vs. 53%, 31/59; p < 0.001). In the US cohort there were no differences. Osmophobia (B = -1.08; p = 0.002) and older age at presentation to the clinic (B = -0.06; p = 0.001) were negative predictors of NDPH-CM. Conclusion NDPH-CM is relatively less migrainous than CM in the UK cohort. Family history of headache is less common in NDPH-CM, with negative predictors for NDPH-CM including osmophobia and older age of presentation to the clinic. More work is required to understand the chronic migraine phenotype of new daily persistent headache.

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