4.8 Article

Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Surgery

Actual Five-year Survival After Upfront Resection for Pancreatic Ductal Adenocarcinoma Who Beats the Odds?

Oliver Strobel et al.

Summary: This study investigated the actual five-year survival rate of pancreatic ductal adenocarcinoma (PDAC) with a strategy of upfront surgery and adjuvant therapy. The results showed that the actual five-year survival rate for PDAC patients who underwent upfront surgery and adjuvant therapy was 18.8%. Tumor grading, number of positive lymph nodes, intraductal papillary mucinous neoplasia, and vascular resections were found to be independent factors associated with the five-year survival rate.

ANNALS OF SURGERY (2022)

Review Gastroenterology & Hepatology

Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment

Laura D. Wood et al.

Summary: This review discusses the pathogenesis, early detection methods, and treatment considerations of pancreatic ductal adenocarcinoma (PDAC). Recent advances in understanding PDAC have led to significant improvements in detection and treatment, but coordinated efforts are needed to maximize clinical impact for patients and overall survival.

GASTROENTEROLOGY (2022)

Article Oncology

Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin

Elisa Espinet et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) has two distinct subtypes, one aggressive subtype with low methylation and high IFN signaling, and another subtype with high methylation and low IFN signaling. These subtypes preserve traits from normal ductal/acinar cells associated with IFN signaling.

CANCER DISCOVERY (2021)

Article Gastroenterology & Hepatology

Single-Nucleus and In Situ RNA-Sequencing Reveal Cell Topographies in the Human Pancreas

Luca Tosti et al.

Summary: By employing single-nucleus RNA-sequencing protocols, this study constructed a comprehensive atlas of human pancreatic cells, identifying novel acinar cell types and highlighting differences in cellular composition in endocrine tissues. Additionally, the research revealed dynamic topographies of pancreatic endocrine and exocrine tissues, as well as potential cellular foundations in certain pancreatic diseases.

GASTROENTEROLOGY (2021)

Review Oncology

Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models

Jin Li et al.

Summary: Pancreatic cancer, especially pancreatic adenocarcinoma, is deadly with low survival rates. Understanding the pre-cancerous lesion IPMN, genetic mutations, and mouse models can provide insight into its development. Research on key signaling pathways and mouse models may help improve diagnostic and treatment strategies for IPMN.

CANCERS (2021)

Review Cell & Tissue Engineering

Stem cells and origins of cancer in the upper gastrointestinal tract

Yoku Hayakawa et al.

Summary: In this article, we discuss the biology of gastroesophageal stem cells and their role as cells of origin in cancer. The interactions between the stromal niche and gastroesophageal stem cells play a vital role in metaplasia and early expansion of mutated stem-cell-derived clones during carcinogenesis. New approaches are being developed to better study gastroesophageal stem cells and advance the field.

CELL STEM CELL (2021)

Review Medicine, General & Internal

Pancreatic Cancer: A Review

Wungki Park et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer with increasing incidence each year, resulting in a high percentage of patients being diagnosed with advanced disease. Current cytotoxic therapies for PDAC are moderately effective, emphasizing the importance of multidisciplinary management, comprehensive germline testing, and integrated supportive care for all patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Cell Biology

Stem/progenitor cells in normal physiology and disease of the pancreas

Mario Enrique Alvarez Fallas et al.

Summary: The existence of stem/progenitor cells in the postnatal mammalian pancreas has been debated, with recent advancements in sequencing and lineage tracing suggesting potential regenerative responses. Single cell transcriptomics has revealed heterogeneity in pancreas cell types, with some cells showing the signature of potential progenitors.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

Article Multidisciplinary Sciences

Genomic characterization of malignant progression in neoplastic pancreatic cysts

Michael Noe et al.

NATURE COMMUNICATIONS (2020)

Article Gastroenterology & Hepatology

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Catherine G. Fischer et al.

GASTROENTEROLOGY (2019)

Review Biochemistry & Molecular Biology

DNA Copy Number Variations as Markers of Mutagenic Impact

Galina Hovhannisyan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors

Prashanth Rawla et al.

WORLD JOURNAL OF ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

High expression of diffuse panbronchiolitis critical region 1 gene promotes cell proliferation, migration and invasion in pancreatic ductal adenocarcinoma

Jiayi Yan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Vinod P. Balachandran et al.

NATURE (2017)

Article Multidisciplinary Sciences

CANCER ETIOLOGY Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Cristian Tomasetti et al.

SCIENCE (2017)

Article Biochemical Research Methods

ChAMP: updated methylation analysis pipeline for Illumina BeadChips

Yuan Tian et al.

BIOINFORMATICS (2017)

Article Gastroenterology & Hepatology

Glycoproteins and glycoproteomics in pancreatic cancer

Sheng Pan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Article Biochemistry & Molecular Biology

A Single-Cell Transcriptome Atlas of the Human Pancreas

Mauro J. Muraro et al.

CELL SYSTEMS (2016)

Article Medicine, General & Internal

Pancreatic cancer

Jorg Kleeff et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Surgery

Patterns of Recurrence After Resection of IPMN Who, When, and How?

Giovanni Marchegiani et al.

ANNALS OF SURGERY (2015)

Review Medicine, General & Internal

Pancreatic Adenocarcinoma

David P. Ryan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medical Laboratory Technology

Intraductal neoplasms of the pancreas

Guenter Kloeppel et al.

SEMINARS IN DIAGNOSTIC PATHOLOGY (2014)

Article Biochemistry & Molecular Biology

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Meritxell Huch et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

EMT and Dissemination Precede Pancreatic Tumor Formation

Andrew D. Rhim et al.

Article Cell Biology

Replication stress and mechanisms of CNV formation

Martin F. Arlt et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2012)

Article Biochemical Research Methods

BEDTools: a flexible suite of utilities for comparing genomic features

Aaron R. Quinlan et al.

BIOINFORMATICS (2010)

Article Multidisciplinary Sciences

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Shinichi Yachida et al.

NATURE (2010)

Article Multidisciplinary Sciences

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

Pawel K. Mazur et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

De La O. Jean-Paul et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)