4.8 Article

Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Faecal immunochemical test for patients with 'high-risk' bowel symptoms: a large prospective cohort study and updated literature review

Helga E. Laszlo et al.

Summary: The study found that using FIT as a tool to rule out CRC comes with a certain miss rate, but combining it with other indicators such as anemia and abdominal pain can reduce the risk of missing cases. FIT can help concentrate medical resources on the most at-risk CRC patients, but further research on safety netting is needed before incorporating FIT triage into the diagnostic pathway.

BRITISH JOURNAL OF CANCER (2022)

Article Medical Laboratory Technology

Comparison of the QuikRead go® point-of-care faecal immunochemical test for haemoglobin with the FOB Gold Wide® laboratory analyser to diagnose colorectal cancer in symptomatic patients

William Maclean et al.

Summary: This study compared the diagnostic accuracy of a point-of-care FIT device (QuikRead go) with a laboratory-based FIT system (FOB Gold Wide) for detecting colorectal cancer. The results showed that both systems were accurate in detecting CRC, but using QuikRead go may result in more patients being triaged for further investigations.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

Article Gastroenterology & Hepatology

ScotCap - A large observational cohort study

Campbell MacLeod et al.

Summary: This study aimed to evaluate the performance of colon capsule endoscopy (CCE) in a lower gastrointestinal diagnostic care pathway. The results showed that CCE is a safe and well-tolerated diagnostic test which can reduce the proportion of patients requiring colonoscopy.

COLORECTAL DISEASE (2022)

Article Medicine, General & Internal

Combining faecal immunochemical testing with blood test results for colorectal cancer risk stratification: a consecutive cohort of 16,604 patients presenting to primary care

Diana R. Withrow et al.

Summary: FIT is a highly sensitive tool for screening colorectal cancer and can identify high-risk individuals with lower risk symptoms in primary care. Combining blood test results with FIT does not appear to improve the screening for colorectal cancer compared to using FIT alone.

BMC MEDICINE (2022)

Review Gastroenterology & Hepatology

Faecal immunochemical tests safely enhance rational use of resources during the assessment of suspected symptomatic colorectal cancer in primary care: systematic review and meta-analysis

Noel Pin-Vieito et al.

Summary: The implementation of FIT as a triage test in primary healthcare can improve referral efficiency without missing cases of CRC. FIT at a threshold of 10 μg/g shows a high sensitivity of 87.2% for CRC, while less than one additional CRC would be missed per 1000 patients investigated at a threshold of 20 μg Hb/g faeces.
Article Medical Laboratory Technology

A comparison of the faecal haemoglobin concentrations and diagnostic accuracy in patients suspected with colorectal cancer and serious bowel disease as reported on four different faecal immunochemical test systems

Sally C. Benton et al.

Summary: This study assessed the comparability of faecal haemoglobin concentrations obtained with four quantitative FIT systems at different thresholds. The results showed differences between systems at lower thresholds, highlighting the need for further understanding of their clinical impact and efforts to minimize these differences.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

Review Health Care Sciences & Services

Optimising GPs' communication of advice to facilitate patients' self-care and prompt follow-up when the diagnosis is uncertain: a realist review of 'safety-netting' in primary care

Claire Friedemann Smith et al.

Summary: This study used a realist review method to provide recommendations for improving safety-netting communication in primary care. The findings emphasize the importance of tailoring advice to patients, providing practical information, ensuring understanding and agreement, and documenting advice in detail for continuity of care.

BMJ QUALITY & SAFETY (2022)

Article Medicine, General & Internal

A cohort study of duplicate faecal immunochemical testing in patients at risk of colorectal cancer from North-West England

Natalie Hunt et al.

Summary: Duplicate faecal immunochemical testing (FIT) can improve the negative and positive predictive value of patients at risk of colorectal cancer (CRC) by reducing the proportion of FIT-negative CRC missed by a single FIT test. This study suggests that in routine NHS practice, a duplicate FIT sample strategy along with clinical evaluation is superior to a single FIT sample alone in managing symptomatic patients in primary care.

BMJ OPEN (2022)

Article Gastroenterology & Hepatology

Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)

Kevin J. Monahan et al.

Summary: Faecal immunochemical testing (FIT) has high sensitivity for detecting colorectal cancer (CRC). This guideline aims to provide a clear strategy for using FIT in the diagnostic pathway of people with signs or symptoms of a suspected CRC diagnosis. The guideline was developed by a multidisciplinary group and includes evidence-based recommendations and research priorities.
Article Surgery

GP access to FIT increases the proportion of colorectal cancers detected on urgent pathways in symptomatic patients in Nottingham

J. A. Bailey et al.

Summary: The study shows that after the introduction of FIT, doctors can more accurately select subjects for urgent investigation, and FIT appears to promote the diagnosis and treatment of early-stage cancer.

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND (2021)

Article Surgery

FIT negative cancers: A right-sided problem? Implications for screening and whether iron deficiency anaemia has a role to play

Laila Cunin et al.

Summary: The study assessed the specificity of FIT and characteristics of FIT negative cancer patients. Results showed high negative predictive value of FIT for cancer, but capturing right sided disease remains a weak point.

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND (2021)

Article Gastroenterology & Hepatology

Optimal diagnostic accuracy of quantitative faecal immunochemical test positivity thresholds for colorectal cancer detection in primary health care: A community-based cohort study

Noel Pin-Vieito et al.

Summary: Optimizing colonoscopy resources in primary health care is challenging. This study assessed the impact of different FIT positivity thresholds on CRC detection in primary care, suggesting that a tailored FIT threshold should be based on colonoscopy capacity and CRC prevalence in specific populations.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2021)

Article Pathology

Service evaluation of faecal immunochemical testing introduced for use in North East London for patients at low risk of colorectal cancer

Ruth M. Ayling et al.

Summary: This study aimed to audit the use of FIT in symptomatic patients and found that FIT had a sensitivity of 87.5% and a specificity of 52.6% for CRC. The study also suggested that patients with anaemia were more likely to have fHb levels greater than or equal to 10 mu g/g.

JOURNAL OF CLINICAL PATHOLOGY (2021)

Article Gastroenterology & Hepatology

Yield of colorectal cancer at colonoscopy according to faecal haemoglobin concentration in symptomatic patients referred from primary care

Stephen T. McSorley et al.

Summary: Symptomatic patients with f-Hb >= 10 mu g/g should undergo further investigation for CRC, while higher f-Hb concentrations could be used to triage for urgency during the COVID-19 recovery phase. Patients with f-Hb <10 mu g/g and without anaemia are very unlikely to be diagnosed with CRC and the majority need no further investigation.

COLORECTAL DISEASE (2021)

Article Gastroenterology & Hepatology

Adoption of faecal immunochemical testing for 2-week-wait colorectal patients during the COVID-19 pandemic: an observational cohort study reporting a new service at a regional centre

William Maclean et al.

Summary: The study shows that incorporating FIT for triage can optimize the allocation of limited resources and improve the efficiency in managing patients who require urgent colonic investigation for detecting colorectal cancer.

COLORECTAL DISEASE (2021)

Article Gastroenterology & Hepatology

Faecal immunochemical test is superior to symptoms in predicting pathology in patients with suspected colorectal cancer symptoms referred on a 2WW pathway: a diagnostic accuracy study

Nigel D'Souza et al.

Summary: The study indicated that the sensitivity of FIT is maximized at the lowest cut-off of 2 mu g/g, reaching 97.0%. A negative FIT result at this cut-off can effectively rule out CRC, while a positive FIT result is better than symptoms for selecting patients for urgent investigations.
Article Surgery

Risk of missing colorectal cancer with a COVID-adapted diagnostic pathway using quantitative faecal immunochemical testing

Y. Maeda et al.

Summary: The COVID-19 pandemic has presented unprecedented challenges to healthcare services. This study suggests that using a single qFIT as a triage test for suspected bowel cancer may lead to a high rate of missed cancers, while adding a second qFIT and CT mini-prep can reduce this risk. However, this approach also increases the rate of colonoscopy or CTVC procedures for patients.

BJS OPEN (2021)

Article Gastroenterology & Hepatology

Use of ColonFlag score for prioritisation of endoscopy in colorectal cancer

Ruth M. Ayling et al.

Summary: This study found that ColonFlag as a triage tool for CRC has equal sensitivity and greater specificity compared to f-Hb concentration at a cut-off of 10 μg/g, and performs better than the FAST test.

BMJ OPEN GASTROENTEROLOGY (2021)

Article Oncology

Diagnostic performance of a faecal immunochemical test for patients with low-risk symptoms of colorectal cancer in primary care: an evaluation in the South West of England

Sarah E. R. Bailey et al.

Summary: This study found that the faecal immunochemical test (FIT) performed well in triaging patients with low-risk symptoms of colorectal cancer, with a positive predictive value of 7.0%, a negative predictive value of 99.8%, a sensitivity of 84.3%, and a specificity of 85.0%.

BRITISH JOURNAL OF CANCER (2021)

Article Medical Laboratory Technology

Faecal haemoglobin concentration thresholds for reassurance and urgent investigation for colorectal cancer based on a faecal immunochemical test in symptomatic patients in primary care

Craig Mowat et al.

Summary: This study examined the clinical outcomes of using f-Hb for CRC risk assessment in primary care, showing that decisions on reassurance or further investigation could be made based on different f-Hb thresholds. However, for patients with iron deficiency anemia, severe symptoms, or persistent symptoms, further investigation should not be denied.

ANNALS OF CLINICAL BIOCHEMISTRY (2021)

Article Medical Laboratory Technology

Assessment of the analytical performance of point-of-care faecal immunochemical tests for haemoglobin

Shane O'Driscoll et al.

Summary: This study evaluated the performance of three point-of-care FIT systems, with QuikRead go and OC-Sensor iO showing good performance and suitability for use, while Eurolyser Cube is not recommended due to the risk of falsely low results.

ANNALS OF CLINICAL BIOCHEMISTRY (2021)

Article Gastroenterology & Hepatology

Using the faecal immunochemical test in patients with rectal bleeding: evidence from the NICE FIT study

Georgina Hicks et al.

Summary: The study found that FIT testing has high sensitivity for ruling out CRC in patients with rectal bleeding, allowing for more appropriate triaging for further investigation and diagnosis.

COLORECTAL DISEASE (2021)

Review Gastroenterology & Hepatology

Systematic review with meta-analysis: Volatile organic compound analysis to improve faecal immunochemical testing in the detection of colorectal cancer

Subashini Chandrapalan et al.

Summary: The combination of FIT and VOC showed effectiveness in detecting CRC, especially in FIT-negative symptomatic populations. With both FIT and VOC negative, there was a significant reduction in the probability of having CRC, providing a safety net for CRC exclusion in primary care. Further evaluation is needed for the cost-effectiveness and clinical accuracy of this approach.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Article Primary Health Care

The Fas Track F T study: diagnostic accuracy of faecal immunochemical test for haemoglobin in patients with suspected colorectal cancer

James L. Turvill et al.

Summary: The study aimed to assess the diagnostic accuracy of FIT in patients suspected of CRC, revealing that FIT can effectively identify CRC and significant premalignant polyps, as well as other organic enteric diseases, potentially facilitating more personalized risk assessment for colorectal cancer.

BRITISH JOURNAL OF GENERAL PRACTICE (2021)

Article Gastroenterology & Hepatology

Performance of the faecal immunochemical test for the detection of colorectal neoplasms and the role of proton pump inhibitors in their diagnostic accuracy

Subashini Chandrapalan et al.

Summary: The study evaluated the performance of FIT in detecting colorectal neoplasms, finding it to be a good rule-out test at lower thresholds. The results showed that PPI therapy did not have a significant effect on the diagnostic performance of FIT.

COLORECTAL DISEASE (2021)

Article Gastroenterology & Hepatology

Colonoscopy Versus Fecal Immunochemical Test for Reducing Colorectal Cancer Risk: A Population-Based Case-Control Study

Su Young Kim et al.

Summary: Colonoscopy is more effective in reducing the risk of distal CRC compared with proximal CRC, while FIT shows weaker risk reduction. However, the association between FIT exposure and CRC prevention strengthens as the frequency of cumulative FIT assessments increases.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2021)

Editorial Material Gastroenterology & Hepatology

Editorial: volatile organic compound analysis to improve faecal immunochemical testing in the detection of colorectal cancer-Authors' reply

Subashini Chandrapalan et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Article Oncology

The impact of changing risk thresholds on the number of people in England eligible for urgent investigation for possible cancer: an observational cross-sectional study

Sarah F. Moore et al.

Summary: Lowering referral thresholds for suspected cancer can expedite diagnosis and increase the number of patients referred for urgent investigation. Data from England showed a significant number of patients with features of possible cancer at different risk thresholds, suggesting that liberalizing the thresholds may not have a substantial impact on resources.

BRITISH JOURNAL OF CANCER (2021)

Article Medical Laboratory Technology

Faecal immunochemical tests for haemoglobin: Analytical challenges and potential solutions

Sally C. Benton et al.

Summary: FIT is increasingly used in colorectal cancer screening and patient symptom assessment, but faces challenges such as pre-analytical variation and quality control materials.

CLINICA CHIMICA ACTA (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Meeting the new joint British Society of Gastrointestinal and Abdominal Radiology and Royal College of Radiologists CT colonography standards: a 6-year experience

O. Duxbury et al.

Summary: The audit demonstrated that the CTC service at St Mark's Hospital is safe and of sufficiently high quality to meet the BSGAR/RCR standards, with most outcomes equal to or above the aspirational target. Areas for service and individual reader improvement were identified. The service was consistently rated good or higher by patients.

CLINICAL RADIOLOGY (2021)

Article Gastroenterology & Hepatology

Finding the needle in the haystack: the diagnostic accuracy of the faecal immunochemical test for colorectal cancer in younger symptomatic patients

Nigel D'Souza et al.

Summary: Detectable fecal hemoglobin on FIT in symptomatic younger patients may indicate referral for investigation of colorectal cancer and serious bowel disease. The sensitivity of FIT for younger patients aged <50 was 87.5%, 81.3%, and 68.8% at different fecal hemoglobin cut-offs, with a high negative predictive value for colorectal cancer at all cut-offs.

COLORECTAL DISEASE (2021)

Article Gastroenterology & Hepatology

Diagnostic accuracy of point of care faecal immunochemical testing using a portable high-speed quantitative analyser for diagnosis in 2-week wait patients

William Maclean et al.

Summary: The laboratory-based faecal immunochemical testing (FIT) is the gold standard for detecting blood in stool, while a point of care (POC) analyser for FIT shows high sensitivity for colorectal cancer (CRC) and serious bowel disease (SBD) in triaging and managing 2-week wait (TWW) colorectal patients. The POC FIT device offers opportunities for improved triage and rationalization of investigation within a single consultation.

COLORECTAL DISEASE (2021)

Article Multidisciplinary Sciences

Colorectal cancer in patients with single versus double positive faecal immunochemical test results: A retrospective cohort study from a public tertiary hospital

Tian Zhi Lim et al.

Summary: Double FIT-positive individuals are significantly more likely to have a colonoscopy finding of incident CRC or premalignant polyp than single FIT-positive individuals. Clinicians and policymakers should consider updating their CRC screening protocols accordingly.

PLOS ONE (2021)

Article Gastroenterology & Hepatology

Quantitative FIT stratification is superior to NICE referral criteria NG12 in a high-risk colorectal cancer population

J. A. Bailey et al.

Summary: This retrospective study on patients undergoing colorectal cancer investigation found that FIT has a higher diagnostic value for colorectal cancer than age and clinical symptoms, and it is also valuable for patients with iron deficiency anaemia.

TECHNIQUES IN COLOPROCTOLOGY (2021)

Article Surgery

Faecal immunochemical testing in symptomatic patients to prioritize investigation: diagnostic accuracy from NICE FIT Study

N. D'Souza et al.

Summary: This study demonstrated that a quantitative faecal immunochemical test can safely select patients with high or low-risk symptoms of colorectal cancer for investigation, with higher positive predictive values for those with high-risk symptoms compared to those with low-risk symptoms.

BRITISH JOURNAL OF SURGERY (2021)

Article Medical Laboratory Technology

Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer

Caroline J. Chapman et al.

Summary: The study found large variations in f-Hb when different FIT devices were used, but smaller variation when the same FIT device was used. This suggests that analyzer-specific f-Hb cut-offs should be applied with regard to clinical decision making, especially at lower f-Hb levels.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

Article Surgery

Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation

J. A. Bailey et al.

Summary: Using FIT in combination with other testing methods can assist in rapid diagnosis of colorectal cancer, but there is a potential for a small number of missed cases. Adjusting referral thresholds and incorporating blood results may improve the accuracy of patient stratification.

BJS OPEN (2021)

Article Surgery

The diagnostic accuracy of the faecal immunochemical test tor colorectal cancer in risk-stratified symptomatic patients

N. D'Souza et al.

ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND (2020)

Article Gastroenterology & Hepatology

Diagnostic accuracy of a quantitative faecal immunochemical test vs. symptoms suspected for colorectal cancer in patients referred for colonoscopy

Georgios Tsapournas et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2020)

Article Oncology

Impact of the faecal immunochemical test on colorectal cancer survival

Maria Angeles Gutierrez-Stampa et al.

BMC CANCER (2020)

Article Public, Environmental & Occupational Health

Colorectal cancer screening completion: An examination of differences by screening modality

Lila J. Finney Rutten et al.

PREVENTIVE MEDICINE REPORTS (2020)

Article Gastroenterology & Hepatology

Faecal immunochemical testing (FIT) in symptomatic patients: what are we missing?

Alexia Farrugia et al.

FRONTLINE GASTROENTEROLOGY (2020)

Review Gastroenterology & Hepatology

Sex-based differences in inflammatory bowel diseases: a review

Sheila D. Rustgi et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2020)

Review Gastroenterology & Hepatology

High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis

Noel Pin Vieito et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Meeting Abstract Medical Laboratory Technology

Faecal immunochemical testing (FIT) for colorectal cancer in symptomatic primary care patients

N. Hunt et al.

CLINICA CHIMICA ACTA (2019)

Article Gastroenterology & Hepatology

Changes in colorectal cancer incidence in seven high-income countries: a population-based study

Marzieh Araghi et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Gastroenterology & Hepatology

Global patterns and trends in colorectal cancer incidence in young adults

Rebecca L. Siegel et al.

Review Primary Health Care

Safety netting for primary care: evidence from a literature review

Daniel Jones et al.

BRITISH JOURNAL OF GENERAL PRACTICE (2019)

Article Gastroenterology & Hepatology

Effect of aspirin on the diagnostic accuracy of the faecal immunochemical test for colorectal advanced neoplasia

Luis Bujanda et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2018)

Review Radiology, Nuclear Medicine & Medical Imaging

Extracolonic Findings at CT Colonography: Systematic Review and Meta-Analysis

Perry J. Pickhardt et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2018)

Article Gastroenterology & Hepatology

Risk stratification of symptomatic patients suspected of colorectal cancer using faecal and urinary markers

M. M. Widlak et al.

COLORECTAL DISEASE (2018)

Article Gastroenterology & Hepatology

Diagnostic accuracy of one or two faecal haemoglobin and calprotectin measurements in patients with suspected colorectal cancer

James Turvill et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2018)

Review Gastroenterology & Hepatology

Post-imaging colorectal cancer or interval cancer rates after CT colonography: a systematic review and meta-analysis

Anu E. Obaro et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Patient experience of CT colonography and colonoscopy after fecal occult blood test in a national screening programme

Andrew A. Plumb et al.

EUROPEAN RADIOLOGY (2017)

Article Oncology

Colorectal cancer statistics, 2017

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

Article Medical Laboratory Technology

Use of a faecal immunochemical test for haemoglobin can aid in the investigation of patients with lower abdominal symptoms

Ian M. Godber et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2016)

Editorial Material Medicine, General & Internal

UNCERTAINTIES Can safety-netting improve cancer detection in patients with vague symptoms?

Brian D. Nicholson et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Editorial Material Medicine, General & Internal

UNCERTAINTIES Can safety-netting improve cancer detection in patients with vague symptoms?

Brian D. Nicholson et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Article Gastroenterology & Hepatology

Comparison of One versus Two Fecal Immunochemical Tests in the Detection of Colorectal Neoplasia in a Population-Based Colorectal Cancer Screening Program

Sarvenaz Moosavi et al.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2016)

Review Gastroenterology & Hepatology

Rising incidence of early-onset colorectal cancer in Australia over two decades: Report and review

Joanne P. Young et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015)

Review Gastroenterology & Hepatology

Prevalence, Risk Factors, and Outcomes of Interval Colorectal Cancers: A Systematic Review and Meta-Analysis

Siddharth Singh et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Use of CT colonography in the English Bowel Cancer Screening Programme

Andrew A. Plumb et al.

Article Gastroenterology & Hepatology

Low faecal haemoglobin concentration potentially rules out significant colorectal disease

P. J. McDonald et al.

COLORECTAL DISEASE (2013)

Article Oncology

Perceived medical discrimination and cancer screening behaviors of racial and ethnic minority adults

LaVera M. Crawley et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2008)

Editorial Material Medicine, General & Internal

GRADE:: what is quality of evidence and why is it important to clinicians?

Gordon H. Guyatt et al.

BMJ-BRITISH MEDICAL JOURNAL (2008)

Article Public, Environmental & Occupational Health

Examination of population-wide trends in barriers to cancer screening from a diffusion of innovation perspective (1987-2000)

LJF Rutten et al.

PREVENTIVE MEDICINE (2004)