Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer

Circular RNAs (circRNAs) are a new type of regulatory RNAs, which have been identified to play critical role in various tumors. However, the profiles and roles of circRNAs in cervical cancer (CCa) have not been fully un-derstood and need to be further explored. In the present study, we performed circRNA array and mRNA-sequencing (mRNA-Seq) to profile the differentially expressed circRNAs and mRNAs in CCa tissues. A total of 397 differentially expressed circRNAs and 2138 differentially expressed mRNAs were detected, respectively. Subsequently, a circRNA-miRNA-mRNA regulatory network was constructed and indicated that hsa_-circ_0026377 was downregulated in CCa. Overexpression of hsa_circ_0026377 inhibited HeLa and SiHa cells proliferation, migration and invasion. Collectively, this study provided new insights into the circRNA profiles in CCa and suggested that hsa_circ_0026377 might play important roles in CCa development.

Automated summary

In this study, circRNA array and mRNA-sequencing were used to profile the differentially expressed circRNAs and mRNAs in cervical cancer (CCa) tissues. The study identified hsa_circ_0026377 as downregulated in CCa and showed that its overexpression inhibited cell proliferation, migration, and invasion in CCa.