期刊
GENE
卷 830, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.gene.2022.146507
关键词
Furanoflavonoid; Karanjin; RNA-seq; Gene expression; Estrogenic activity; Estrogen receptor
资金
- Department of Science and Technology, Govt. of India [CRG/2020/002109]
- IIT Guwahati
Karanjin, a furanoflavonoid compound, has diverse biological effects in vivo and in vitro. This study explored the transcriptomic footprint of Karanjin in MCF-7 breast cancer cells, revealing its potential estrogen-like activity and cautioning its anticancer potential. Further investigations are needed to understand the mechanism of action.
Karanjin, an abundantly occurring furanoflavonoid in edible and non-edible legumes, exerts diverse biological effects in vivo, and in vitro. Its potential as an anticancer agent is gaining traction following recent demonstrations of its anti-proliferative, cell cycle inhibitory, and pro-apoptotic effects. However, the genomic correlates of these activities are not known. In the present study we delineated the transcriptomic footprint of 10 mu M karanjin in MCF-7 breast cancer cells, using next generation sequencing technology (RNA-seq). We show that karanjin-modulated gene-expression repertoire is enriched in several hallmark gene sets, which include early estrogen-response, and G2/M checkpoint genes. Genes modulated by karanjin overlapped with those modulated by 1 nM 17 beta-estradiol (E2), or 1 mu M tamoxifen. The results suggest partial estrogen-like activity of karanjin, thereby presenting a caveat to its anticancer potential. Further investigations into its mechanisms of action are warranted to ascertain the true potential of karanjin in anticancer, or endocrine therapy.
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