期刊
FUTURE MICROBIOLOGY
卷 17, 期 11, 页码 861-871出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2021-0174
关键词
biofilms; modeling; Pseudomonas aeruginosa; quorum sensing
类别
The study shows that zeolites can disrupt the QS systems of Chromobacterium violaceum and Pseudomonas aeruginosa by adsorbing AHL signal molecules, reducing their production and virulence. This finding may provide new insights for the treatment of P. aeruginosa-related infections.
Aim: To investigate the hypothesis that zeolites interfere with quorum-sensing (QS) systems of Chromobacterium violaceum and Pseudomonas aeruginosa by adsorbing N-acyl homoserine lactone (AHL) signal molecules. Methods: QS inhibition by zeolite 4A was investigated using an AHL-based bioreporter assay. The adsorption of the AHLs was evaluated by performing inductively coupled plasma-optical emission spectroscopy and confirmed by Monte Carlo and molecular dynamic simulations. Results: Zeolite 4A reduced the violacein production in C. violaceum by over 90% and the biofilm formation, elastase and pyocyanin production in P. aeruginosa by 87, 68 and 98%, respectively. Conclusion: Zeolite 4A disrupts the QS systems of C. violaceum and P. aeruginosa by means of adsorbing 3-oxo-C6-AHL and 3-oxo-C12-AHL signaling molecules and can be developed as a novel QS jammer to combat P. aeruginosa-related infections.
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