期刊
FUTURE MICROBIOLOGY
卷 17, 期 12, 页码 969-982出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2021-0291
关键词
animal model; antifungal agents; computational method; cryptococcosis; invertebrate model; pharmacodynamics; pharmacokinetics
类别
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [303373/2019-9]
This review describes and discusses the main mammal animal models for PK and PD studies of antifungals used in cryptococcosis treatment. Alternative models and computational methods are also addressed. All approaches for PK/PD studies are relevant to investigating drug-infection interaction and improving cryptococcosis therapy.
Studies on cryptococcosis in the mammal animal model have demonstrated the occurrence of central nervous system infection and similarities in fungal pathogenicity with clinical and immunological features of the human infection. Although there is still a lack of studies involving pharmacokinetics (PK) and pharmacodynamics (PD) in animal models of cryptococcosis in the literature, these experimental models are useful for understanding this mycosis and antifungal effectiveness in improving the therapeutic schemes. The scope of this review is to describe and discuss the main mammal animal models for PK and PD studies of antifungals used in cryptococcosis treatment. Alternative models and computational methods are also addressed. All approaches for PK/PD studies are relevant to investigating drug-infection interaction and improving cryptococcosis therapy.
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