4.7 Article

Mitochondrial-derived vesicles: Gatekeepers of mitochondrial response to oxidative stress

期刊

FREE RADICAL BIOLOGY AND MEDICINE
卷 188, 期 -, 页码 185-193

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2022.06.233

关键词

Mitochondria; Mitochondrial quality control; Mitochondrial-derived vesicle; Aging; Diseases; Therapeutics

资金

  1. National Natural Science Foundation of China [81971214]

向作者/读者索取更多资源

Mitochondrial quality control mechanisms ensure the stability and function of mitochondria. Mitochondrial-derived vesicles play a crucial role in defending against oxidative stress. Abnormal MDVs can disrupt metabolite clearance and immune response, leading to pathological conditions.
Mitochondrial quality control (MQC) mechanisms are a series of adaptive responses that ensure the relative stability of mitochondrial morphology, quantity, and quality to preserve cellular survival and function. While MQC mechanisms range from mitochondrial biogenesis and fusion/fission to mitophagy, mitochondrial-derived vesicles (MDVs) may represent an essential component of MQC. MDVs precede mitochondrial autophagy and serve as the first line of defense against oxidative stress by selectively transferring damaged mitochondrial substances to the lysosome for degradation. In fact, the function of MDVs is dependent on the cargo, the shuttle route, and the ultimate destination. Abnormal MDVs disrupt metabolite clearance and the immune response, predisposing to pathological conditions, including neurodegeneration, cardiovascular diseases, and cancers. Therefore, MDV regulation may be a potential therapeutic for the therapy of these diseases. In this review, we highlight recent advances in the study of MDVs and their misregulation in various diseases from the perspectives of formation, cargo selection, regulation, and transportation.

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