期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 188, 期 -, 页码 262-276出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2022.06.238
关键词
NRF2; UVA; UVB; Ultraviolet; Photodermatosis; Photocarcinogens; Photodamage; Pharmacological intervention; Sulforaphane
资金
- COST (European Cooperation in Science and Technology) [CA20121]
- Israel Ministry of Science and Tech-nology, Regional RD Centers [3-16752]
- Cancer Research UK [C20953/A18644]
- BBSRC [BB/T017546/1, BB/T508111/1]
- Ninewells Cancer Campaign
- Reata Pharmaceuticals
The skin barrier and its protective mechanisms are constantly dealing with external stressors, with ultraviolet radiation (UVR) being a major threat. Comprehensive strategies and pharmacological treatments are essential for protecting against photocarcinogenesis and exacerbation of photodermatosis conditions. Activation of NRF2 offers comprehensive and long-lasting protection by upregulating cytoprotective proteins to counteract the damaging effects of UVR.
The skin barrier and its endogenous protective mechanisms cope daily with exogenous stressors, of which ultraviolet radiation (UVR) poses an imminent danger. Although the skin is able to reduce the potential damage, there is a need for comprehensive strategies for protection. This is particularly important when developing pharmacological approaches to protect against photocarcinogenesis. Activation of NRF2 has the potential to provide comprehensive and long-lasting protection due to the upregulation of numerous cytoprotective downstream effector proteins that can counteract the damaging effects of UVR. This is also applicable to photodermatosis conditions that exacerbate the damage caused by UVR. This review describes the alterations caused by UVR in normal skin and photosensitive disorders, and provides evidence to support the development of NRF2 activators as pharmacological treatments. Key natural and synthetic activators with photoprotective properties are summarized. Lastly, the gap in knowledge in research associated with photodermatosis conditions is highlighted.
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