4.7 Article

The effect of Holder pasteurization on the lipid and metabolite composition of human milk

期刊

FOOD CHEMISTRY
卷 384, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2022.132581

关键词

Donor human milk; Holder pasteurization; Preterm infant; Metabolomics; Lipidomics; Network analysis

资金

  1. Instituto de Salud Carlos III, Spain [CD19/00176, CP16/00034]
  2. Ministry of Science and Innovation, Spain [IJC2018-036209-I]
  3. Generalitat Valenciana [GV/2021/186]
  4. European Union [818110]
  5. H2020 Societal Challenges Programme [818110] Funding Source: H2020 Societal Challenges Programme

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This study analyzed the impact of Holder pasteurization on the metabolic and lipidomic composition of human milk. The results showed a significant decrease in fatty acids and alterations in multiple metabolic pathways. Lipidomic analysis provided further insights into the effect of pasteurization on physical and chemical properties, cellular components, and functions.
Human milk (HM) is the gold standard for newborn nutrition. When own mother's milk is not sufficiently available, pasteurized donor human milk becomes a valuable alternative. In this study we analyzed the impact of Holder pasteurization (HoP) on the metabolic and lipidomic composition of HM. Metabolomic and lipidomic profiles of twelve paired HM samples were analysed before and after HoP by liquid chromatography-mass spectrometry (MS) and gas chromatography-MS. Lipidomic analysis enabled the annotation of 786 features in HM out of which 289 were significantly altered upon pasteurization. Fatty acid analysis showed a significant decrease of 22 out of 29 detectable fatty acids. The observed changes were associated to five metabolic pathways. Lipid ontology enrichment analysis provided insight into the effect of pasteurization on physical and chemical properties, cellular components, and functions. Future research should focus on nutritional and/or developmental consequences of these changes.

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