Differential surface partitioning for an ultrasensitive solid-state SERS sensor and its application to food colorant analysis

Solid-state SERS sensors are desirable point-of-care tools due to their portability. However, the level of SERS sensitivity achieved in liquid phase is rarely duplicated in the solid phase. We report herein the fabrication of a SERS sensor using alumina beads as the solid support and demonstrate its high SERS sensitivity with the model analyte 4-aminophenyl disulfide (4-APDS). The key to sensitivity is a hydrophilic-hydrophobic surface gradient constructed by sequentially coating with the surfactant cetyltrimethylammonium bromide and fluorous 1H,1H,2H,2H-perfluorooctyltriethoxysilane. The surface gradient, together with chloride etching, allows the detection of 4-APDS at the low concentration of 10(-15) M. The practicality of the sensor beads is evidenced by successfully tracking the SERS fingerprints of five food colorant standards in the SERS spectra of a popular candy product. These SERS sensor beads are easy to prepare, convenient to use, and highly responsive as a SERS platform for the analysis of colorants.

Automated summary

We report the fabrication of a SERS sensor using alumina beads as the solid support and demonstrate its high sensitivity with the model analyte 4-APDS. The key to sensitivity is a hydrophilic-hydrophobic surface gradient constructed by sequentially coating with surfactant and fluorous silane. The practicality of the sensor beads is evidenced by successfully tracking the SERS fingerprints of five food colorant standards.