Synthesis of a Dual Metal-Organic Framework Heterostructure as a Fluorescence Sensing Platform for Rapid and Sensitive Detection of Tetracycline in Milk and Beef Samples

A new metal-organic framework heterostructure composite (MOF@MOF, ZIF-8 @PCN-128Y) was synthesized by an internal extension growth method and used as a sensor for the detection of tetracycline (TC). In this method, TC was enriched by virtue of the adsorption capacity of ZIF-8 and detected by PCN-128Y acting as an optical tentacle in virtue of its luminescence advantage. TC was rapidly detected with sensitivity and selectivity, and the limit of detection was 60 nM. At the same time, this method has good linearity and a wide linear range. TC in milk and beef samples was determined by this sensor, and the recovery rate was 94.2-106.3%. This work provided guidance for the construction and application of the MOF@MOF fluorescence sensor.

Automated summary

A new metal-organic framework heterostructure composite (MOF@MOF) was synthesized and used as a sensor for the detection of tetracycline (TC). The sensor showed rapid detection, sensitivity, and selectivity with a limit of detection of 60 nM. It also displayed good linearity and a wide linear range, and was successfully applied to determine TC in milk and beef samples.