期刊
FERTILITY AND STERILITY
卷 118, 期 3, 页码 568-575出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2022.05.029
关键词
CD138; chronic endometritis; endometrial polyp; hysteroscopic surgery; intrauterine adhesion
资金
- JSPS KAKENHI, Japan [18K09273]
The study aimed to investigate the prevalence and risk factors of chronic endometritis (CE) in patients with intrauterine disorders and the therapeutic efficacy of hysteroscopic surgery in treating CE. The results showed that endometrial polyp and intrauterine adhesion were risk factors for CE, and most CE cases in infertile patients could be cured with hysteroscopic surgery.
Objective: To identify the prevalence of and risk factors for chronic endometritis (CE) in patients with intrauterine disorders and the therapeutic efficacy of hysteroscopic surgery in the treatment of CE without antibiotic therapy. Design: Prospective cohort study. Setting: Hospital specializing in reproductive medicine. Patient(s): The study population consisted of 350 women with infertility, of whom 337 were recruited, who underwent hysteroscopic surgery between November 2018 and June 2021. Eighty-nine consecutive patients without intrauterine disorders were also recruited as controls. Intervention(s): Endometrial samples were collected during the surgery for CD 138 immunostaining for the diagnosis of CE. In women diagnosed with CE, endometrial biopsy was performed without antibiotic use in the subsequent menstrual cycle. Main Outcome Measure(s): Prevalence of and risk factors for CE in intrauterine disorders and therapeutic effects of hysteroscopic surgery on CE. Result(s): The prevalence of CE with >= 5 CD138-positive cells in women with no intrauterine disorder and with endometrial polyps, myomas, intrauterine adhesions (IUAs), and septate uterus was 15.7%, 85.7%, 69.0%, 78.9%, and 46.2%, respectively. A multivariate analysis revealed that CE was diagnosed significantly more often in the endometrial polyp (odds ratio, 27.69; 95% confidence interval, 15.01-51.08) and IUA groups (odds ratio, 8.85; 95% confidence interval, 3.26-24.05). The rate of recovery from CE with surgery in women with endometrial polyps, myomas, IUA, and septate uterus was 89.7%, 100%, 92.8%, and 83.3%, respectively. Conclusion(s): Endometrial polyp and RA were risk factors for CE. Most CE cases with intrauterine disorders were cured with hysteroscopic surgery without antibiotic therapy, regardless of the type of intrauterine abnormalities. (Fertil Steril (R) 2022;118:568-75. (C) 2022 by American Society for Reproductive Medicine.)
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