4.7 Article

Maternal L-carnitine supplementation promotes brown adipose tissue thermogenesis of newborn goats after cold exposure

期刊

FASEB JOURNAL
卷 36, 期 8, 页码 -

出版社

WILEY
DOI: 10.1096/fj.202200637R

关键词

brown adipose tissue; cold exposure; L-carnitine; lipidomics; thermogenesis

资金

  1. National Key Research and Development Program of China [2021YFD1100202]

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This study found that maternal L-carnitine supplementation promotes BAT development and thermogenesis in newborn goats. The lipid composition of BAT was also altered by L-carnitine supplementation.
Brown adipose tissue (BAT) is an important component of energy expenditure and necessary to maintain body temperature for newborn mammals. In the previous study, we found that L-carnitine was enriched in BAT and promoted BAT adipogenesis and thermogenesis in goat brown adipocytes. However, whether dietary L-carnitine regulates BAT heat production and energy expenditure in lambs remains unclear. In this study, maternal L-carnitine supplementation elevated the rectal temperature, as well as the expression of UCP1 and mitochondrial DNA content to promote BAT thermogenesis in newborn goats. Moreover, maternal L-carnitine supplementation increased the levels of triglycerides (TG), non-esterified fatty acids (NEFA), and lactate in plasma, as well as the content of lipid droplet and glycogen in BAT of newborn goats. Lipidomic analysis showed that maternal L-carnitine supplementation remodeled the lipid composition of BAT in newborn goats. L-carnitine significantly increased the levels of TG and diglyceride (DG) and decreased the levels of glycerophospholipids and sphingolipids in BAT. Further studies showed that L-carnitine promoted TG and glycogen deposition in brown adipocytes through AMPK alpha. Our results indicate that maternal L-carnitine supplementation promotes BAT development and thermogenesis in newborn goats and provides new evidence for newborn goats to maintain body temperature in response to cold exposure.

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