期刊
FASEB JOURNAL
卷 36, 期 7, 页码 -出版社
WILEY
DOI: 10.1096/fj.202101853RR
关键词
genetics; preeclampsia; pregnancy-induced hypertension; single nucleotide polymorphisms; susceptibility
资金
- National Key R & D Program of China [2018YFC1004300]
- National Natural Science Foundation Project of China [82160154, 81670844]
- Key Project of Guizhou Provincial Science and Technology Department [QKH-JC-2019-1464]
- Excellent Talent Support Program of Guizhou Provincial Education Department [QJH-KY-2017-077]
- Science and Technology Foundation of Guizhou Province [QKH-PTRC-2017-5733-003, QKH-PTRC-2018-5772-042]
- Program for Excellent Young Talents of Zunyi Medical University [18-ZY-001, F-874]
- Science and Technology Program Project of Zunyi [ZSKH-HZ-2020-35]
Pregnancy-induced hypertension (PIH) is a severe pregnancy complication that can lead to maternal mortality. Various genetic factors have been shown to play an important role in the occurrence and development of PIH. This review summarizes the genetic risk factors involved in the renin-angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks that may contribute to the pathogenesis of PIH.
Pregnancy-induced hypertension (PIH) is a multifactorial and severe pregnancy complication including preeclampsia/eclampsia, gestational hypertension, chronic (pre-existing) hypertension, and preeclampsia/eclampsia variants superimposed on chronic hypertension. PIH-induced maternal mortality accounts for approximately 9% of all maternal deaths over the world. A large number of case-control studies have established the importance of various genetic factors in the occurrence and development of PIH. In this narrative review, we summarized the genetic risk factors involved in the renin-angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks, with the aim of sorting out the genetic factors that may play a potential role in PIH and providing new ideas to elucidate the pathogenesis of PIH.
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