4.5 Review

Current emerging and investigational drugs for the treatment of chronic hand eczema

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Article Dermatology

Prevalence and Severity of Hand Eczema in the Dutch General Population: A Cross-sectional, Questionnaire Study within the Lifelines Cohort Study

Angelique N. Voorberg et al.

Summary: There is limited data on chronic hand eczema and its severity in the general population. This cross-sectional study investigated the prevalence and severity of hand eczema in the Dutch population through a questionnaire. The results showed that the lifetime prevalence of hand eczema was 15.0%, the 1-year prevalence was 7.3%, and the self-reported physician-diagnosed prevalence was 6.1%. The study also found that the majority of subjects with hand eczema had almost clear symptoms at their worst, and the prevalence of severe to very severe hand eczema in the general population was 1.9%. The study suggests that future epidemiological research should include data on chronic hand eczema and its severity to gain a better understanding of the burden of hand eczema.

ACTA DERMATO-VENEREOLOGICA (2022)

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The long-term effect of dupilumab on chronic hand eczema in patients with moderate to severe atopic dermatitis-52 week results from the Dutch BioDay Registry

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Efficacy and safety of ruxolitinib cream for the treatment of atopic dermatitis: Results from 2 phase 3, randomized, double-blind studies

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Expression of retinoid receptors in hand eczema

Hanan Rabea Nada et al.

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Latent class analysis categorizes chronic hand eczema patients according to skin barrier impairment

M. Tauber et al.

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Review Dermatology

Hand eczema: treatment

P. Elsner et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Hand eczema: epidemiology, prognosis and prevention

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Safe and effective use of alitretinoin in children with recalcitrant hand eczema and other dermatoses - a retrospective analysis

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Delgocitinib: First Approval

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The Unique Molecular Signatures of Contact Dermatitis and Implications for Treatment

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Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation

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Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis

Emma Guttman-Yassky et al.

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Current and emerging therapies for hand eczema

Griffin R. Lee et al.

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Chronic hand eczema and hepatogenic pruritus with good response to apremilast

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A Retrospective Review of Dupilumab for Hand Dermatitis

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Calcipotriol ointment shows comparable efficacy to topical steroids in chronic hand eczema

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Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study

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Crisaborole and atopic dermatitis skin biomarkers: An intrapatient randomized trial

Robert Bissonnette et al.

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JAK Inhibitors for Atopic Dermatitis: An Update

Helen He et al.

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A Phase 2 Randomized Trial of Apremilast in Patients with Atopic Dermatitis

Eric L. Simpson et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Emerging Topical and Systemic JAK Inhibitors in Dermatology

Farzan Solimani et al.

FRONTIERS IN IMMUNOLOGY (2019)

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The association between atopic dermatitis and hand eczema: a systematic review and meta-analysis

S. M. D. Ruff et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Synergistic cytokine effects as apremilast response predictors in patients with psoriasis

Sandra Garcet et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Dupilumab treatment in moderate-to-severe atopic dermatitis: A systematic review and meta-analysis

Fa-Ping Wang et al.

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Dupilumab for hand eczema

Matthew J. Zirwas

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Dupilumab Treatment of Very Severe Refractory Atopic Hand Eczema

Jart A. F. Oosterhaven et al.

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Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

Heng Li et al.

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Letter Dermatology

Apremilast treatment of atopic dermatitis and other chronic eczematous dermatoses

Michael Abrouk et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

Letter Dermatology

Acitretin as a Therapeutic Option for Chronic Hand Eczema

Margaret Song et al.

ANNALS OF DERMATOLOGY (2017)

Article Dermatology

Drug survival of cyclosporine in the treatment of hand eczema: a multicentre, daily use study

W. A. Christoffers et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2016)

Letter Dermatology

Drug survival of methotrexate treatment in hand eczema patients: results from a retrospective daily practice study

K. Politiek et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2016)

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New therapies for psoriasis and psoriatic arthritis

Christopher T. Ritchlin et al.

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Alitretinoin: A Review in Severe Chronic Hand Eczema

Hannah A. Blair et al.

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Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation

Nan-Lin Wu et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

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Atopic dermatitis

Stephan Weidinger et al.

LANCET (2016)

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The hand eczema proteome: imbalance of epidermal barrier proteins

S. Molin et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

Article Biochemistry & Molecular Biology

New pathogenic and therapeutic paradigms in atopic dermatitis

Dana Malajian et al.

CYTOKINE (2015)

Article Dermatology

Guidelines for diagnosis, prevention and treatment of hand eczema

Thomas L Diepgen et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2015)

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Classification of hand eczema

T. Agner et al.

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Successful treatment of refractory chronic hand eczema with calcipotriol/betamethasone ointment: A report of three cases

Min Yang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)

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Open-label exploratory study of acitretin for the treatment of severe chronic hand dermatitis

Jerry Tan et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2015)

Article Dermatology

Management of Chronic Hand Eczema

F. J. de Leon et al.

ACTAS DERMO-SIFILIOGRAFICAS (2015)

Article Allergy

Immunomodulation in Patients with Chronic Hand Eczema Treated with Oral Alitretinoin

Mandana Schindler et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2014)

Article Allergy

Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response

Nikhil Dhingra et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Article Allergy

Cost of illness from occupational hand eczema in Germany

Thomas L. Diepgen et al.

CONTACT DERMATITIS (2013)

Review Dermatology

Acitretin in dermatology

Rashmi Sarkar et al.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2013)

Article Allergy

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Julia K. Gittler et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Pharmacology & Pharmacy

Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease

Apostolos Kontzias et al.

CURRENT OPINION IN PHARMACOLOGY (2012)

Article Medicine, General & Internal

Hand Eczema

Pieter-Jan Coenraads

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Allergy

Tight junction defects in patients with atopic dermatitis

Anna De Benedetto et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)

Article Dermatology

Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema

R. Bissonnette et al.

BRITISH JOURNAL OF DERMATOLOGY (2010)

Review Immunology

Janus kinases in immune cell signaling

Kamran Ghoreschi et al.

IMMUNOLOGICAL REVIEWS (2009)

Article Immunology

Selectivity and therapeutic inhibition of kinases: to be or not to be?

Kamran Ghoreschi et al.

NATURE IMMUNOLOGY (2009)

Article Allergy

Hand eczema: causes, course, and prognosis II

Niels K. Veien et al.

CONTACT DERMATITIS (2008)

Article Allergy

Hand eczema: causes, course, and prognosis I

Niels K. Veien et al.

CONTACT DERMATITIS (2008)

Article Biochemistry & Molecular Biology

Structural basis for the activity of drugs that inhibit phosphodiesterases

GL Card et al.

STRUCTURE (2004)

Article Dermatology

Experience with low-dose methotrexate for the treatment of eczema in the elderly

FCG Shaffrali et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2003)