期刊
EXPERIMENTAL NEUROLOGY
卷 354, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2022.114086
关键词
Post-operative sleep disorder; Propofol; General anesthesia; Circadian rhythm; Melatonin
资金
- National Key New Drug Creation Program [2017ZX09309020]
Postoperative sleep disorders are common in patients after surgery, with general anesthesia-induced circadian rhythm disturbances playing a significant role. Prolonged propofol anesthesia affects sleep, body temperature, activity, and endogenous melatonin secretion, leading to reduced oscillation amplitude. Melatonin pretreatment shows potential therapeutic effects in restoring circadian rhythm and preventing over-synthesis of melatonin after propofol anesthesia.
Postoperative sleep disorder frequently occurs in patients after surgery. Sleep disturbance aggravates pain, anxiety, and delirium, which is an important risk factor for poor recovery. Circadian rhythm disorder induced by general anesthesia plays important role in postoperative sleep disorders. A large number of clinical studies have shown that various forms and duration of general anesthesia can lead to postoperative sleep disorders. In this study, the effect of prolonged propofol anesthesia on biological rhythm was comprehensively evaluated by wireless physiological telemetry system, and the therapeutic effect of exogenous melatonin pretreatment was further investigated. The results showed that prolonged propofol anesthesia had significant impacts on the circadian rhythm of sleep, body temperature, locomotor activity and endogenous melatonin secretion within 24 h following anesthesia, resulting in diminished oscillation amplitude. In hypothalamus, the expression of circadian factor PER and CRY were inhibited by propofol, possibly through activation of CAMK-CREB signaling pathway. Post-translational factors GSK-3 beta, SIRT1, AMPK were also involved in the regulation of circadian factors after propofol anesthesia. Melatonin pretreatment could restore circadian rhythm process by regulating circadian factor expression through post-translational modulation and prohibit the over-synthesis of melatonin in pineal gland. This study verified the effects of anesthetics on circadian rhythm and further evaluated the potential therapeutic effect of melatonin on postoperative circadian rhythm and sleep disorders.
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