期刊
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/8809546
关键词
-
资金
- Zhongshan Municipal Bureau of Science and Technology [2019AG035]
- GBA Institute of Collaborate Innovation [GICI-022]
- Key-Area Research and Development Program of Guangdong Province [2020B1111110006]
- Guangzhou Science and Technology Committee Research Grant [GZSTI16SC02, GZSTI17SC02]
- Special project of Foshan University of Science and Technology [FSUST19-SRI10]
- Hong Kong RGC-GFC [16100921]
- Hong Kong RGC Theme-based Research Scheme [T13-605/18-W]
- Hong Kong Innovation Technology Fund [PRP/076/20FX, UIM/385, ITS/500/18FP, ITCPD/17-9, TUYF19SC02, PD18SC01, HMRF18SC06, HMRF20SC07, AFD20SC01]
- Shenzhen Science and Technology Innovation Committee [ZDSYS201707281432317]
This study aimed to develop an anti-depressant from a group of food/medicine called medicinal food homology. The herbal mixture of Sesami Semen Nigrum and Longan Arillus showed neurotrophic activity and improved symptoms of depression in cell culture and animal models.
Medicinal food homology is referring to a group of food itself being considered as herbal medicine without a boundary of usage. Under the guidance of this food/medicine principle, the current study aims to develop anti-depressant from this food/medicine catalog. The herbal mixture of Sesami Semen Nigrum and Longan Arillus was evaluated in cultured PC12 rat pheochromocytoma cells, rat primary cortical neurons, and in chronic mild stress (CMS)-induced depressive rat model. The combination of two ethanolic extracts of Sesami Semen Nigrum and Longan Arillus in 1 : 1 ratio mimicked the function of nerve growth factor (NGF) and synergistically induced neurite outgrowth of PC12 cells. Besides, the expression and phosphorylation of tropomyosin receptor kinase A (TrkA) of the cultured cells were also elevated. This neurotrophic activity of herbal mixture was further supported by the increased expressions of biomarkers for neurogenesis and synaptogenesis in cortical neurons. Moreover, the depressed rats were soothed by the intake of herbal mixture, showing improved performance in behavior tests, as well as reversed levels of neurotransmitters and neurotrophic factors. Our results provide a new way to make full use of the current food/medicine resources, as to accelerate the development of therapeutics for depression.
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