Venous Claudication: a Scoping Review of the Pathophysiology and Clinical Importance

Objective: Venous claudication (VC) is under studied, often being excluded from clinical trials and scales. The purpose of this scoping review was to give a historical perspective of VC and analyse the prevalence, pathophysiological aspects, and clinical implications. Methods: An extensive search of the books and databases (PubMed, MEDLINE, Scopus, and Cochrane) was performed from inception until October 2021. Studies were considered eligible provided they reported on the topics of interest, whereas strict exclusion criteria with regards to the studied sample of patients, year of publication, or location of the obstruction could not be applied, because of the limited relevant literature. Results: Twenty nine articles were included. VC is found almost exclusively in patients with iliofemoral obstruction. Prevalence was reported in seven studies having a wide range from 10.6% to 74.0%. Dominant findings include increased venous volume and pressure. Pressure in capillaries also rises subsequently causing compartment oedema and increased intramuscular pressure resulting in tissue ischaemia and hypoxia. The time required for the venous pressure to return to the pre-exercise levels in the affected limbs is prolonged compared with normal (39.1 +/- 14.4 seconds vs. 1.1 +/- 1.1 seconds). Conclusion: VC is an important symptom of venous outflow obstruction that is under studied, and merits further recognition. Better understanding of the pathophysiology will be achieved through investigations at tissue level. Diagnosis and improvement after treatment should be reported in an objective and standardised manner.

Automated summary

This scoping review provides a historical perspective of venous claudication (VC) and analyzes its prevalence, pathophysiological aspects, and clinical implications. The findings suggest that VC is almost exclusively found in patients with iliofemoral obstruction and is characterized by increased venous volume and pressure. The time required for venous pressure to return to pre-exercise levels is prolonged compared to normal. VC is an important symptom of venous outflow obstruction that is under studied and merits further recognition.