Targeted inhibition of TGF-β type I receptor by AZ12601011 protects against kidney fibrosis

Article Chemistry, Multidisciplinary

Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis

Fang Wang et al.

Summary: The study demonstrates that SFN enhances programmed cell death and inflammation caused by cisplatin or I/R via interacting with RIPK3, suggesting it may serve as a promising therapeutic target for AKI treatment.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Cell Biology

Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms

Jia-Nan Wang et al.

Summary: The role of N-6-methyladenosine (m6A) modifications in renal diseases, particularly acute kidney injury (AKI), is still largely unknown. In this study, the researchers investigated the role of N-6-adenosine-methyltransferase-like 3 (METTL3) in AKI and found that its expression is elevated in renal tubules. They discovered that silencing METTL3 alleviated renal inflammation and programmed cell death in tubular epithelial cells (TECs) in response to stimulation, while overexpression of METTL3 had the opposite effects. Conditional knockout of METTL3 in mice also attenuated renal dysfunction, injury, and inflammation induced by AKI. Furthermore, the researchers identified TAB3 as a target of METTL3 and explored its proinflammatory effects. They also investigated the therapeutic potential of inhibiting METTL3 using an inhibitor called Cpd-564. Overall, they concluded that the METTL3/TAB3 axis may be a potential target for the treatment of AKI.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Correction Multidisciplinary Sciences

A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling (January, 10.1038/s41467-022-28096-z, 2022)

Qian Yuan et al.

NATURE COMMUNICATIONS (2022)

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Article Dermatology

Heterogeneous addiction to transforming growth factor-beta signalling in recessive dystrophic epidermolysis bullosa-associated cutaneous squamous cell carcinoma

J. H. S. Dayal et al.

Summary: The study found that by blocking endogenous signaling, TGFBR1 kinase inhibitors can significantly inhibit proliferation, clonogenicity, migration, and invasion of the majority of RDEB cSCCs. However, the potential tumor suppressive role of TGF-beta signaling in a subset of RDEB cSCCs requires biomarker identification for patient stratification before clinical intervention.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Review Pharmacology & Pharmacy

Mineralocorticoid receptor antagonists in patients with chronic kidney disease

Cosimo Cosimato et al.

Summary: MRA can reduce cardiovascular morbidity and mortality in patients with heart failure and ischemic heart disease, and also have been used in patients with diabetic nephropathy to control proteinuria. Currently, guidelines recommend against the use of MRAs in patients with advanced CKD, but there is growing interest in their use in this population.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Urology & Nephrology

Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study

Edouard L. Fu et al.

Summary: The study found that stopping RAS inhibitor therapy in patients with advanced CKD was associated with higher risks of mortality and major adverse cardiovascular events, but lower risk of initiating kidney replacement therapy (KRT).

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Urology & Nephrology

The case for early identification and intervention of chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Michael G. Shlipak et al.

Summary: Chronic kidney disease (CKD) is a significant global burden associated with higher morbidity and mortality, especially among individuals with lower socioeconomic status. Despite the availability of guidelines for evaluating and managing early CKD, there is still a lack of consensus on prioritizing early identification and intervention for CKD without incentives or quality measures.

KIDNEY INTERNATIONAL (2021)

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Article Pharmacology & Pharmacy

Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Chenchen Han et al.

Summary: The study revealed that GRK2 plays a key role in regulating FLS proliferation by translocating to EP4, and CP-25 improves FLS function by inhibiting the kinase domain of GRK2. This targeted inhibition of GRK2 kinase domain by CP-25 could represent an innovative approach for treating RA.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Medicine, Research & Experimental

Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts

Yen-Ting Chen et al.

Summary: Renal fibrosis is a common pathological manifestation of chronic kidney disease without effective therapy. TXNDC5, identified as a critical mediator of cardiac fibrosis, is upregulated in fibrotic kidneys and may play a potential role in renal fibrosis.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Urology & Nephrology

Comparative Effectiveness of Renin-Angiotensin System Inhibitors and Calcium Channel Blockers in Individuals With Advanced CKD: A Nationwide Observational Cohort Study

Edouard L. Fu et al.

Summary: The study suggests that initiating RAS inhibitor therapy in patients with advanced chronic kidney disease may confer kidney benefits and provide similar cardiovascular protection compared to initiating CCB therapy.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Review Medicine, General & Internal

Chronic kidney disease

Kamyar Kalantar-Zadeh et al.

Summary: Chronic kidney disease is a progressive disease with no cure, and preserving kidney function through lifestyle adjustments and pharmacological interventions can improve outcomes. A plant-dominant, low-protein, and low-salt diet may help mitigate glomerular hyperfiltration and preserve renal function. Various pharmacotherapies can also be used to alter intrarenal haemodynamics and protect the kidney from further damage.

LANCET (2021)

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Article Urology & Nephrology

CKD in China: Evolving Spectrum and Public Health Implications

Chao Yang et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

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Article Chemistry, Multidisciplinary

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Xiao-qiang Geng et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Multidisciplinary Sciences

TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1

Jie Su et al.

NATURE (2020)

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Review Cell Biology

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Natascha Roehlen et al.

CELLS (2020)

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Review Urology & Nephrology

Targeting the progression of chronic kidney disease

Marta Ruiz-Ortega et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Article Chemistry, Multidisciplinary

Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway

Zhi-quan Chen et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Biochemistry & Molecular Biology

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway

Ya-ru Yang et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

SB431542-Loaded Liposomes Alleviate Liver Fibrosis by Suppressing TGF-β Signaling

Jinhang Zhang et al.

MOLECULAR PHARMACEUTICS (2020)

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Article Physiology

Overexpression of TGF-β1 induces renal fibrosis and accelerates the decline in kidney function in polycystic kidney disease

Yan Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Cellular and molecular mechanisms of kidney fibrosis

Sonja Djudjaj et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

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Review Medicine, Research & Experimental

Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)

Pacific Huynh et al.

CLINICAL SCIENCE (2019)

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Article Medicine, Research & Experimental

RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress

Jia-nan Wang et al.

CLINICAL SCIENCE (2019)

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Article Medicine, Research & Experimental

Promotion of β-catenin/Foxo1 signaling ameliorates renal interstitial fibrosis

Padmashree Rao et al.

LABORATORY INVESTIGATION (2019)

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Article Biochemistry & Molecular Biology

Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress

Hao Liu et al.

REDOX BIOLOGY (2019)

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Article Pharmacology & Pharmacy

Praziquantel ameliorates CCl4-induced liver fibrosis in mice by inhibiting TGF-β/Smad signalling via up-regulating Smad7 in hepatic stellate cells

Jinfeng Liu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Exosomes from high glucose-treated macrophages activate glomerular mesangial cells via TGF-β1/Smad3 pathway in vivo and in vitro

Qi-Jin Zhu et al.

FASEB JOURNAL (2019)

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Editorial Material Transplantation

A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases

Kitty J. Jager et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2019)

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Article Pharmacology & Pharmacy

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors

Lindsay C. Spender et al.

MOLECULAR PHARMACOLOGY (2019)

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Article Medicine, Research & Experimental

Conditional knockout of TGF-βRII/Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation

Qin Yang et al.

THERANOSTICS (2019)

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Review Physiology

Mechanisms of Renal Fibrosis

Benjamin D. Humphreys

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

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Article Medicine, Research & Experimental

The preventive and therapeutic implication for renal fibrosis by targetting TGF-β/Smad3 signaling

Yun Zhang et al.

CLINICAL SCIENCE (2018)

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Review Biochemistry & Molecular Biology

Targeting TGF-β Signaling in Kidney Fibrosis

Yoshitaka Isaka

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Medicine, Research & Experimental

TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration

Sungjin Chung et al.

JCI INSIGHT (2018)

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Review Medicine, General & Internal

Chronic kidney disease

Angela C. Webster et al.

LANCET (2017)

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Review Pharmacology & Pharmacy

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

Kelly L. Walton et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Review Urology & Nephrology

TGF-β: the master regulator of fibrosis

Xiao-ming Meng et al.

NATURE REVIEWS NEPHROLOGY (2016)

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Article Biochemistry & Molecular Biology

EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling

Sang-A Park et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

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Review Transplantation

Transforming growth factor-β and the progression of renal disease

Ivonne Loeffler et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2014)

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Review Cell Biology

Non-Smad signaling pathways

Yabing Mu et al.

CELL AND TISSUE RESEARCH (2012)

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Article Urology & Nephrology

TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

Wei Qin et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

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Review Urology & Nephrology

Cellular and molecular mechanisms of renal fibrosis

Youhua Liu

NATURE REVIEWS NEPHROLOGY (2011)

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Article Urology & Nephrology

Smad2 Protects against TGF-β/Smad3-Mediated Renal Fibrosis

Xiao Ming Meng et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

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Review Urology & Nephrology

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

Robert L. Chevalier et al.

KIDNEY INTERNATIONAL (2009)

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Review Biochemistry & Molecular Biology

Role of anti-TGF-β antibodies in the treatment of renal injury

E Gagliardini et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2006)

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Targeted inhibition of TGF-β type I receptor by AZ12601011 protects against kidney fibrosis

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