Selective N-Deacetylation and Functionalization of Aminosugars

N-Acetyl groups are abundant functional groups found in a variety of biomolecules including aminosugars. N-Acetyl groups are chemically stable and harsh conditions are often needed to remove them. Herein, we report a mild and efficient protocol to remove N-acetyl groups in the presence of esters and carbamates and functionalize the resulting amine in a one-pot manner.

Automated summary

A mild and efficient protocol for the removal of N-acetyl groups in biomolecules, such as aminosugars, is reported. The resulting amine can be functionalized in a one-pot manner.