期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2022, 期 32, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202200792
关键词
1; 6-Conjugate Addition; Enaminone; 4H-Chromene; 4H-Chromen-4-one; p-Quinone methides
资金
- SERB [CRG/2019/000236]
- IISER Mohali
- UGC, New Delhi
- DST
A one-pot method has been developed for synthesizing oxygen-containing heterocycles in moderate to excellent yields through a series of chemical reactions.
A one-pot approach for the synthesis of oxygen-containing heterocycles such as 4H-chromenes and 4H-chromen-4-ones has been established through the reaction of enaminones with p-quinone methides (p-QMs). This transformation basically involves an acid-catalyzed 1,6-conjugate addition of enaminones to p-QMs followed by annulation. In the case of reaction between 2-hydroxyphenyl-substituted p-quinone methides and N,N-dimethyl enaminones, 4H-chromene derivatives were obtained in moderate to excellent yields. Similarly, the reaction between simple p-quinone methides and 2-hydroxyphenyl-substituted N,N-dimethyl enaminones led to 4H-chromen-4-one derivatives in good yields.
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