期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 56, 期 2, 页码 3825-3838出版社
WILEY
DOI: 10.1111/ejn.15726
关键词
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资金
- Science Foundation Ireland grant [SFI 13/IA/2014]
Place cells have been found in the rat claustrum, exhibiting location-dependent responses and being modulated by visual inputs. Remapping of place cells in the claustrum is NMDA receptor-dependent when visual inputs are eliminated from the environment.
Place cells are cells that exhibit location-dependent responses; they have mostly been studied in the hippocampus. Place cells have also been reported in the rat claustrum, an underexplored paracortical region with extensive corto-cortical connectivity. It has been hypothesised that claustral neuronal responses are anchored to cortical visual inputs. We show rat claustral place cells remap when visual inputs are eliminated from the environment, and that this remapping is NMDA-receptor-dependent. Eliminating visual input decreases claustral delta-band oscillatory activity, increases theta-band oscillatory activity, and increases simultaneously recorded visual cortical activity. We conclude that, like the hippocampus, claustral place field remapping might be mediated by NMDA receptor activity, and is modulated by visual cortical inputs.
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