相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Impact of PROTAC Linker Plasticity on the Solution Conformations and Dissociation of the Ternary Complex
Dhanushka Weerakoon et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2022)
Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies
Xufen Yu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders
Xufen Yu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Integrative Modeling of PROTAC-Mediated Ternary Complexes
Gaoqi Weng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta
Nan Bai et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)
Transforming targeted cancer therapy with PROTACs: A forward-looking perspective
William Farnaby et al.
CURRENT OPINION IN PHARMACOLOGY (2021)
An updated patent review of Akt inhibitors (2016-present)
Yu Guo et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2021)
Discovery and resistance mechanism of a selective CDK12 degrader
Baishan Jiang et al.
NATURE CHEMICAL BIOLOGY (2021)
AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?
Federica Martorana et al.
FRONTIERS IN PHARMACOLOGY (2021)
Unraveling the Role of Linker Design in Proteolysis Targeting Chimeras
Troy A. Bemis et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity
Jinxin Che et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Alesa Bricelj et al.
FRONTIERS IN CHEMISTRY (2021)
Targeting PI3K/Akt signal transduction for cancer therapy
Yan He et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
Raghu Vannam et al.
CELL CHEMICAL BIOLOGY (2021)
E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
Tasuku Ishida et al.
SLAS DISCOVERY (2021)
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
George M. Burslem et al.
CELL (2020)
Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy
Xin Li et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)
Spotlight on AKT: Current Therapeutic Challenges
Ina Landel et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
PROTAC Technology: Opportunities and Challenges
Hongying Gao et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies
Michael L. Drummond et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
Inchul You et al.
CELL CHEMICAL BIOLOGY (2020)
Development and Characterization of a Wee1 Kinase Degrader
Zhengnian Li et al.
CELL CHEMICAL BIOLOGY (2020)
PROTACs: An Emerging Therapeutic Modality in Precision Medicine
Dhanusha A. Nalawansha et al.
CELL CHEMICAL BIOLOGY (2020)
The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism
Gerta Hoxhaj et al.
NATURE REVIEWS CANCER (2020)
In Silico Modeling of PROTAC-Mediated Ternary Complexes: Validation and Application
Michael L. Drummond et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Acquired Resistance to BET-PROTACs (Proteolysis-Targeting Chimeras) Caused by Genomic Alterations in Core Components of E3 Ligase Complexes
Lu Zhang et al.
MOLECULAR CANCER THERAPEUTICS (2019)
Protein Interaction Z Score Assessment (PIZSA): an empirical scoring scheme for evaluation of protein-protein interactions
Ankit A. Roy et al.
NUCLEIC ACIDS RESEARCH (2019)
Targeted protein degradation: elements of PROTAC design
Stacey-Lynn Paiva et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2019)
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
Xiaowu Dong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Interaction of Mantle Cell Lymphoma with the Microenvironment Induces Phospho Akt-Mediated Resistance Against BTK Inhibition and Can be Overcome By Co-Treatment with a Specific Akt Inhibitor (MK-2206)
Elisabeth Silkenstedt et al.
BLOOD (2019)
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
Wenhu Zhan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Targeting AKT for cancer therapy
Maryam Shariati et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2019)
Targeted protein degradation: expanding the toolbox
Matthieu Schapira et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Pharmacodynamic Study of Miransertib in Individuals with Proteus Syndrome
Kim M. Keppler-Noreuil et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2019)
Plasticity in binding confers selectivity in ligand-induced protein degradation
Radoslaw P. Nowak et al.
NATURE CHEMICAL BIOLOGY (2018)
Delineating the role of cooperativity in the design of potent PROTACs for BTK
Adelajda Zorba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Maximising the potential of MKT inhibitors as anti-cancer treatments
Jessica S. Brown et al.
PHARMACOLOGY & THERAPEUTICS (2017)
SynergyFinder: a web application for analyzing drug combination dose-response matrix data
Aleksandr Ianevski et al.
BIOINFORMATICS (2017)
Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL
Tabea Erdmann et al.
BLOOD (2017)
AKT/PKB Signaling: Navigating the Network
Brendan D. Manning et al.
CELL (2017)
The PI3K/AKT Pathway as a Target for Cancer Treatment
Ingrid A. Mayer et al.
ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)
Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors
Wenhu Zhan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor
Jean-Marc Lapierre et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Degradation of Akt using protein-catalyzed capture agents
Ryan K. Henning et al.
JOURNAL OF PEPTIDE SCIENCE (2016)
Novel agents and associated toxicities of inhibitors of the PI3K/Akt/mTOR pathway for the treatment of breast cancer
S. Chia et al.
CURRENT ONCOLOGY (2015)
Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer
Khanh Do et al.
INVESTIGATIONAL NEW DRUGS (2015)
Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways
Xiaoxian Zhao et al.
BRITISH JOURNAL OF HAEMATOLOGY (2015)
Integrating docking scores, interaction profiles and molecular descriptors to improve the accuracy of molecular docking: Toward the discovery of novel Akt1 inhibitors
Wenhu Zhan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Structure-based design, synthesis and biological evaluation of diphenylmethylamine derivatives as novel Akt1 inhibitors
Tao Liu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor
Melissa Dumble et al.
PLOS ONE (2014)
Lenalidomide induces degradation of IKZF1 and IKZF3
Jan Kroenke et al.
ONCOIMMUNOLOGY (2014)
Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases
Matt Addie et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
Michael L. Wang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors
James F. Blake et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors
Xiaowu Dong et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape
Margrith E. Mattmann et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2011)
Impact of linker length on the activity of PROTACs
Kedra Cyrus et al.
MOLECULAR BIOSYSTEMS (2011)
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
Hiroshi Hirai et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma
Jessica Dal Col et al.
BLOOD (2008)
Deregulation of the Akt pathway in human cancer
Eriko Tokunaga et al.
CURRENT CANCER DRUG TARGETS (2008)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Perturbations of the AKT signaling pathway in human cancer
DA Altomare et al.
ONCOGENE (2005)
The Akt/PKB pathway: molecular target for cancer drug discovery
JQ Cheng et al.
ONCOGENE (2005)
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
I Vivanco et al.
NATURE REVIEWS CANCER (2002)