期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 238, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2022.114454
关键词
Click chemistry; Drug development; Molecular hybridization; Triazole; Tuberculosis
资金
- Council of Scientific & In-dustrial Research [02 (0345) /19/EMR-II]
- Institute of Eminence (IoE) , Banaras Hindu University
This review summarizes the recent innovation of triazole-appended hybrids with in vitro and in vivo antitubercular activity. By analyzing the structure-activity relationship, it aims to assist medicinal chemists in exploring triazole scaffolds for the rational design of potent drug candidates with improved efficacy, selectivity, and minimal toxicity.
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million deaths in the year 2019. Due to the growing number of drug-sensitive and drug-resistant tuberculosis cases, there is a vital need to develop new and effective candidates useful to combat this deadly disease. Despite tremendous efforts to identify a mechanism-based novel antitubercular agent, only a few have entered into clinical trials in the last six decades. In recent years, triazoles have been well explored as the most valuable scaffolds in drug discovery and development. Triazole framework possesses favorable properties like hydrogen bonding, moderate dipole moment, enhanced water solubility, and also the ability to bind effectively with biomolecular targets of M. tuberculosis and therefore this scaffold displayed excellent potency against TB. This review is an endeavor to summarize an up-to-date innovation of triazole-appended hybrids during the last 10 years having potential in vitro and in vivo antitubercular activity with structure activity relationship analysis. This review may help medicinal chemists to explore the triazole scaffolds for the rational design of potent drug candidates having better efficacy, improved selectivity and minimal toxicity so that these hybrid NCEs can effectively be explored as potential lead to fight against M. tuberculosis.
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