期刊
EUROPEAN JOURNAL OF INTERNAL MEDICINE
卷 104, 期 -, 页码 7-12出版社
ELSEVIER
DOI: 10.1016/j.ejim.2022.06.003
关键词
Diabetes; Type 1 diabetes; Autoimmune diabetes; Immunogenetics; Treatment
资金
- Twin Trust
- Barts Charity [MGU0513]
- European Foundation for the Study of Diabetes [MMBP1C3R]
- BLUEPRINT Stud [282510]
Type 1 diabetes can occur in adults and may not require insulin therapy initially. This review compares adult-onset and childhood-onset type 1 diabetes, discusses their epidemiology, genetics, diagnostic criteria, and management, and also looks at the psychosocial challenges faced by T1D patients and how to manage them.
Type 1 diabetes most commonly presents in adulthood, contrary to the widely held view that it is a disease of childhood. Furthermore, a substantial proportion of cases of adult-onset type 1 diabetes does not require insulin therapy at clinical onset. Recent studies have emphasised the evidence that adult-onset type 1 diabetes is prevalent but often misclassified initially as type 2 diabetes (1, 2). In this review, we discuss that recent liter-ature, highlighting the similarities and differences between adult-onset and childhood-onset type 1 diabetes, exploring recent debates surrounding its epidemiology and genetics, as well as expanding on important issues of diagnostic criteria for individuals presenting with adult-onset diabetes and the subsequent management once identified as having an autoimmune basis. In addition, this review looks at the psychosocial challenges faced by T1D patients and their possible management.
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