期刊
EUROPEAN JOURNAL OF HEART FAILURE
卷 24, 期 8, 页码 1441-1449出版社
WILEY
DOI: 10.1002/ejhf.2596
关键词
Heart failure; Heart failure with preserved ejection fraction; Diastolic function; Cell therapy
资金
- Slovenian Research Agency [J3-9283]
- Stanford Cardiovascular Institute
The study showed that CD34(+) cell therapy in patients with HFpEF resulted in improvements in E/e', NT-proBNP, exercise capacity, and local myocardial strain at the cell injection sites.
Aims We investigated the effects of CD34(+) cell therapy in patients with heart failure with preserved ejection fraction (HFpEF). Methods and results In a prospective pilot study, we enrolled 30 patients with HFpEF. In Phase 1, patients were treated with medical therapy for 6 months. Thereafter, all patients underwent CD34(+) cell transplantation. Using electroanatomical mapping, we measured local mechanical diastolic delay and myocardial viability to guide the targeting of cell injections. Patients were followed for 6 months after cell transplantation (Phase 2), and the primary endpoint was the difference in change in E/e ' between Phase 1 and Phase 2. In Phase 1, the decrease in E/e ' was significantly less pronounced than in Phase 2 (-0.33 +/- 1.72 vs. -3.77 +/- 2.66, p = 0.001). During Phase 1, there was no significant change in global systolic strain (GLS; from -12.5 +/- 2.4% to -12.8 +/- 2.6%, p = 0.77), N-terminal pro-B-type natriuretic peptide (NT-proBNP; from 1463 +/- 1247 pg/ml to 1298 +/- 931 pg/ml, p = 0.31), or 6-min walk test (6MWT; from 391 +/- 75 m to 402 +/- 93 m, p = 0.42). In Phase 2, an improvement was noted in NT-proBNP (from 1298 +/- 931 pg/ml to 887 +/- 809 pg/ml, p = 0.02) and 6MWT (from 402 +/- 93 m to 438 +/- 72 m, p = 0.02). Although GLS did not change significantly in Phase 2 (from -12.8 +/- 2.6% to -13.8 +/- 2.7%, p = 0.36), we found improved local systolic strain at cell injection sites (-3.4 +/- 6.8%, p = 0.005). Conclusions In this non-randomized trial, transendocardial CD34(+) cell therapy in HFpEF was associated with an improvement in E/e ', NT-proBNP, exercise capacity, and local myocardial strain at the cell injection sites. Clinical Trial Registration: ClinicalTrials.gov NCT02923609.
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